Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system

In analogy to normal stem cell differentiation, the current cancer stem cell (CSC) model presumes a hierarchical organization and an irreversible differentiation in tumor tissue. Accordingly, CSCs should comprise only a small subset of the tumor cells, which feeds tumor growth. However, some recent...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12103-e12103
Hauptverfasser:	Wegwitz, Florian, Kluth, Mark-Andreas, Mänz, Claudia, Otto, Benjamin, Gruner, Katharina, Heinlein, Christina, Kühl, Marion, Warnecke, Gabriele, Schumacher, Udo, Deppert, Wolfgang, Tolstonog, Genrich V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Apoptosis Ataxin Biomarkers - metabolism Breast cancer Cancer Carcinoma Cell Biology/Cell Growth and Division Cell Biology/Gene Expression Cell Communication Cell Differentiation Cell Line, Tumor Cell surface Clone Cells Cytoskeleton Developmental Biology/Stem Cells Differentiation (biology) Epigenetics Epithelial Cells - pathology Gene expression Gene Expression Profiling Genetic engineering Heterogeneity Histology Homeostasis Humans Immunology Intermediate filament proteins Lymphocytes T Mammary gland Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - pathology Markers Medical research Mesenchyme Mesoderm - pathology Metastasis Mice Mice, Transgenic MicroRNAs Models, Biological Morphogenesis Mutation Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology/Breast Cancer Phenotype Proteins Repopulation Rodents Sox10 protein Stem cells Surface markers T cells Transcription factors Transcription Factors - metabolism Transcription, Genetic Transgenic mice Tumor cells Tumors Vimentin Virology Wireless Internet access
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