Direct visualization of protease action on collagen triple helical structure

Enzymatic processing of extracellular matrix (ECM) macromolecules by matrix metalloproteases (MMPs) is crucial in mediating physiological and pathological cell processes. However, the molecular mechanisms leading to effective physiological enzyme-ECM interactions remain elusive. Only scant informati...

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Veröffentlicht in:	PloS one 2010-06, Vol.5 (6), p.e11043-e11043
Hauptverfasser:	Rosenblum, Gabriel, Van den Steen, Philippe E, Cohen, Sidney R, Bitler, Arkady, Brand, David D, Opdenakker, Ghislain, Sagi, Irit
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Bioavailability Biochemistry Biochemistry/Macromolecular Assemblies and Machines Biophysics/Macromolecular Assemblies and Machines Collagen Collagen (type II) Collagen - chemistry Collagen - metabolism Collagenase Cytokines Degradation Denaturation Electrophoresis, Polyacrylamide Gel Enzymes Extracellular matrix Extracellular Matrix - metabolism Fragmentation Fragments Gelatin Gelatinase Gelatinase B Inflammation Laboratories Macromolecules Matrix metalloproteinases Matrix Metalloproteinases - metabolism Medical research Microscopy, Atomic Force Molecular modelling Neutrophil collagenase Neutrophils Peptides Physiological aspects Physiology Protease Proteases Protein Conformation Protein denaturation Proteinase Proteins Proteolysis Science Substrates Visualization Yoga
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