Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans

Iron overload is known to exacerbate many infectious diseases, and conversely, iron withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for Cryptococcus neoformans because the fungus senses iron to regulate elaboration of the polysaccharide capsule that is the ma...

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Veröffentlicht in:	PLoS biology 2006-12, Vol.4 (12), p.e410-e410
Hauptverfasser:	Jung, Won Hee, Sham, Anita, White, Rick, Kronstad, James W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS-Related Opportunistic Infections - microbiology Amino Acid Sequence Animals Biological Transport Calcium - metabolism Cell Wall - metabolism Cell Wall - microbiology Cryptococcosis - microbiology Cryptococcus Cryptococcus neoformans - genetics Cryptococcus neoformans - metabolism Cryptococcus neoformans - pathogenicity Fungal Proteins - genetics Fungal Proteins - metabolism Fungal Proteins - physiology Gene expression Gene Expression Regulation, Fungal Genetics/Genomics/Gene Therapy Health aspects HIV/AIDS Infectious Diseases Iron - metabolism Iron in the body Laccase - genetics Laccase - metabolism Medical research Mice Microbiology Molecular Sequence Data Mutation Proteins RNA, Messenger - metabolism Sequence Alignment Temperature Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Virulence (Microbiology) Virulence Factors - genetics Virulence Factors - metabolism Yeast and Fungi
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