Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma

Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the electron transport chain. Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors paraganglioma (PGL) and pheochromocytoma (...

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Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7987-e7987
Hauptverfasser:	Bayley, Jean-Pierre, van Minderhout, Ivonne, Hogendoorn, Pancras C W, Cornelisse, Cees J, van der Wal, Annemieke, Prins, Frans A, Teppema, Luc, Dahan, Albert, Devilee, Peter, Taschner, Peter E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal medulla Anesthesiology Animal tissues Animals Carotid body Dehydrogenases Deoxyribonucleic acid Diabetes and Endocrinology/Multiple Endocrine Disorders and Neoplasias DNA E coli Electron transport Electron transport chain Embryogenesis Escherichia coli Female Gene Expression Regulation, Neoplastic Genes Genes, Tumor Suppressor Genetics Genetics and Genomics/Animal Genetics Genetics and Genomics/Cancer Genetics Genomes Genomics Genotype Heart diseases Heterozygote Hyperplasia Hypertrophy Hypoxia Internal controls Lethality Life span Male Metabolism Mice Mice, Knockout Mitochondria Mouse devices Mutation Neuroendocrine tumors Otolaryngology/Head and Neck Cancers Paraganglioma Paraganglioma - genetics Pathology Phenotype Pheochromocytoma Pheochromocytoma - genetics Physiological aspects Protein turnover Proteins RNA, Long Noncoding RNA, Untranslated - genetics Rodents Succinate dehydrogenase Succinate Dehydrogenase - genetics Tricarboxylic acid cycle Tumor suppressor genes Tumorigenesis Tumors
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