Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD

Age-related macular degeneration (AMD) is a leading cause of legal blindness in the elderly in the industrialized word. While the immune system in the retina is likely to be important in AMD pathogenesis, the cell biology underlying the disease is incompletely understood. Clinical and basic science...

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Veröffentlicht in:	PloS one 2009-11, Vol.4 (11), p.e7945-e7945
Hauptverfasser:	Ma, Wenxin, Zhao, Lian, Fontainhas, Aurora M, Fariss, Robert N, Wong, Wai T
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Angiogenesis Animal models Animals Blindness Cells (Biology) Cellular structure Chemotaxis Coculture Techniques Epithelial cells Epithelium Eye (anatomy) Gene expression Geriatrics Immune System Inflammation Leukocyte migration Macular degeneration Macular Degeneration - pathology Mice Mice, Inbred C57BL Mice, Transgenic Microglia Microglia - metabolism Models, Biological Neovascularization Neovascularization, Physiologic Older people Ophthalmology Ophthalmology/Macular Disorders Ophthalmology/Retinal Disorders Optic Nerve - metabolism Pathogenesis Photoreceptors Physiology Quantitative analysis Retina Retina - metabolism Retinal pigment epithelium Retinal Pigment Epithelium - metabolism Structure-function relationships Vascularization
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