Spontaneous emergence of multiple drug resistance in tuberculosis before and during therapy

The emergence of drug resistance in M. tuberculosis undermines the efficacy of tuberculosis (TB) treatment in individuals and of TB control programs in populations. Multiple drug resistance is often attributed to sequential functional monotherapy, and standard initial treatment regimens have therefo...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e18327-e18327
Hauptverfasser:	Colijn, Caroline, Cohen, Ted, Ganesh, Ayalvadi, Murray, Megan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antitubercular agents Bacilli Bacteria Biology Control programs Drug resistance Emergence Epidemiology Gene expression Humans Isoniazid - pharmacology Isoniazid - therapeutic use Medicine Microbial drug resistance Multidrug resistance Mutagenesis Mutation Mycobacterium smegmatis Mycobacterium tuberculosis Population Probability Probability distribution Public health Stochasticity Therapy Time Factors Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy
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