Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody

Activated platelets can be found on the surface of inflamed, rupture-prone and ruptured plaques as well as in intravascular thrombosis. They are key players in thrombosis and atherosclerosis. In this study we describe the construction of a radiolabeled single-chain antibody targeting the LIBS-epitop...

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Veröffentlicht in:	PloS one 2011-03, Vol.6 (3), p.e18446-e18446
Hauptverfasser:	Heidt, Timo, Deininger, Friederike, Peter, Karlheinz, Goldschmidt, Jürgen, Pethe, Annette, Hagemeyer, Christoph E, Neudorfer, Irene, Zirlik, Andreas, Weber, Wolfgang A, Bode, Christoph, Meyer, Philipp T, Behe, Martin, von Zur Mühlen, Constantin
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Antibodies Antigenic determinants Apoptosis Arteries Arteriosclerosis Atherosclerosis Autoradiography Blood clots Blood platelets Cardiology Carotid arteries Carotid artery Carotid Artery Thrombosis - diagnostic imaging Carotid Artery Thrombosis - physiopathology CAT scans Chains Computed tomography Diabetes Epitopes Epitopes - immunology Histology Immunoglobulins In vivo methods and tests Incubation Indium Radioisotopes Inflammation Injury analysis Isotope Labeling - methods Laboratory animals Ligands Medical imaging Medicine Mice Neurosciences NMR Nuclear magnetic resonance Nuclear medicine Pathogenesis Plaques Platelet Activation - physiology Platelets Protein Binding Single photon emission computed tomography Single-Chain Antibodies Thromboembolism Thrombosis Tomography Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Veins & arteries
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