Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Aβ), which triggers a cellular stress response called the unfolded protein response (UPR). The UPR signaling pathway is a cellular defense system for dealing with the accumulation of misfolded proteins but s...

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Veröffentlicht in:	PloS one 2010-05, Vol.5 (5), p.e10489
Hauptverfasser:	Lee, Do Yeon, Lee, Kyu-Sun, Lee, Hyun Jung, Kim, Do Hee, Noh, Yoo Hun, Yu, Kweon, Jung, Hee-Yeon, Lee, Sang Hyung, Lee, Jun Young, Youn, Young Chul, Jeong, Yoonhwa, Kim, Dae Kyong, Lee, Won Bok, Kim, Sung Su
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aging Alzheimer's disease Apoptosis Biology Biotechnology Brain research Cancer Caspase Caspase-4 Cell Biology/Cellular Death and Stress Responses Cellular stress response Endoplasmic reticulum Kinases Medicine Molecular modelling Neuroblastoma cells Neurodegenerative diseases Neurological diseases Neurological Disorders Neurological Disorders/Alzheimer Disease Neurons Neuropeptides Neurotoxicity Pathogenesis Peptides Protein folding Proteins Rodents Signal transduction Signaling Stress Stresses Studies Switches Therapeutic applications Transcription factors Trends β-Amyloid
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