LIGHT induces distinct signals to clear an AAV-expressed persistent antigen in the mouse liver and to induce liver inflammation

Infection with adeno-associated virus (AAV) vector with liver tropism leads to persistent expression of foreign antigens in the mouse liver, with no significant liver inflammation or pathology. This provides a model to investigate antigen persistence in the liver and strategies to modulate host immu...

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Veröffentlicht in:	PloS one 2010-05, Vol.5 (5), p.e10585-e10585
Hauptverfasser:	Washburn, Michael L, Kovalev, Grigoriy I, Koroleva, Ekaterina, Fu, Yang-Xin, Su, Lishan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adenovirus Adenoviruses Advertising executives Analysis Animals Antigens Antigens, Viral - immunology Biophysics CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cell growth Clearing Curricula Dendritic cells Deoxyribonucleic acid Dependovirus - genetics Dependovirus - immunology DNA Effector cells Genes Genetic vectors Genome, Viral - genetics Genomes Hepatitis Hepatocytes Immunity Immunoglobulins Immunology Immunology/Immunity to Infections Immunology/Immunomodulation Infections Inflammation Inflammation - pathology Inflammation - virology Light Liver Liver - pathology Liver - virology Liver cancer Liver diseases Lymphocytes Lymphocytes T Lymphotoxin beta Receptor - deficiency Mice Molecular biology Parvoviridae Infections - pathology Parvoviridae Infections - virology Proteins Rodents Signal Transduction - immunology T cells Tropism Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism Tumor necrosis factor-TNF Tumors Viral infections Virology/Immune Evasion Virology/New Therapies, including Antivirals and Immunotherapy Virology/Vaccines Viruses
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