The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance

Overlapping roles have been ascribed for T cell anergy, clonal deletion, and regulation in the maintenance of peripheral immunological tolerance. A measurement of the individual and additive impacts of each of these processes on systemic tolerance is often lacking. In this report we have used adopti...

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Veröffentlicht in:	PLoS biology 2006-11, Vol.4 (11), p.e340-e340
Hauptverfasser:	Singh, Nevil J, Chen, Chuan, Schwartz, Ronald H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Biological - immunology Adoptive Transfer Animals Antigens Arthritis - etiology Arthritis - immunology Autoantibodies - physiology Autoimmune Diseases - immunology B-Lymphocytes - physiology CD40 Antigens - metabolism CD40 Ligand - metabolism Cell Differentiation - immunology Cells, Cultured Clonal Anergy Cytokines Cytokines - physiology Experiments Immune system Immune Tolerance - physiology Immunological tolerance Immunology Immunosuppression Lymphocyte Activation - physiology Lymphocytes Mammals Mice Mice, Transgenic Mus (Mouse) Pathology Protein Binding Proteins T cell receptors T-Lymphocytes - physiology Vertebrates Viral infections
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