Rationalisation of the differences between APOBEC3G structures from crystallography and NMR studies by molecular dynamics simulations

The human APOBEC3G (A3G) protein is a cellular polynucleotide cytidine deaminase that acts as a host restriction factor of retroviruses, including HIV-1 and various transposable elements. Recently, three NMR and two crystal structures of the catalytic deaminase domain of A3G have been reported, but...

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Veröffentlicht in:PloS one 2010-07, Vol.5 (7), p.e11515-e11515
Hauptverfasser: Autore, Flavia, Bergeron, Julien R C, Malim, Michael H, Fraternali, Franca, Huthoff, Hendrik
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Sprache:eng
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