Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms

Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon cancers. Fifty-one population-based MSS colon cancers w...

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Veröffentlicht in:	PloS one 2009-12, Vol.4 (12), p.e8308-e8308
Hauptverfasser:	Jung, Barbara, Gomez, Jessica, Chau, Eddy, Cabral, Jennifer, Lee, Jeffrey K, Anselm, Aimee, Slowik, Przemyslaw, Ream-Robinson, Deena, Messer, Karen, Sporn, Judith, Shin, Sung K, Boland, C Richard, Goel, Ajay, Carethers, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin activin receptors Activin Receptors, Type I - genetics Activin Receptors, Type II - genetics Analysis Biotechnology Bisulfite Cancer Cancer genetics Cell Line, Tumor Colon Colon cancer Colonic Neoplasms - classification Colonic Neoplasms - genetics Colorectal cancer Deactivation Demethylation Disruption DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetic inheritance Epigenetics Exons Fluorescence Gastroenterology Gastroenterology and Hepatology/Colon and Rectum Gastroenterology and Hepatology/Gastrointestinal Cancers Gastrointestinal diseases Gene expression Gene Expression Regulation, Neoplastic Genetics and Genomics/Cancer Genetics Genetics and Genomics/Epigenetics Genomic instability Growth factors Heterozygosity Humans Inactivation Kinases Loss of heterozygosity Loss of Heterozygosity - genetics Medicine Methylation Microsatellite Instability Microsatellite Repeats - genetics Microsatellites mRNA Mutation Mutation - genetics Polymerase chain reaction Promoter Regions, Genetic - genetics Promoters Protein expression Proteins Signal transduction Signal Transduction - genetics Signaling Smad2 Protein - genetics Stability Stability analysis Sulfites Transcription, Genetic Tumor Burden - genetics Tumor cell lines Tumors Western blotting
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