Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development

PACSIN/Syndapin proteins are membrane-active scaffolds that participate in endocytosis. The structure of the Drosophila Syndapin N-terminal EFC domain reveals a crescent shaped antiparallel dimer with a high affinity for phosphoinositides and a unique membrane-inserting prong upon the concave surfac...

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Veröffentlicht in:	PloS one 2009-12, Vol.4 (12), p.e8150
Hauptverfasser:	Edeling, Melissa A, Sanker, Subramaniam, Shima, Takaki, Umasankar, P K, Höning, Stefan, Kim, Hye Y, Davidson, Lance A, Watkins, Simon C, Tsang, Michael, Owen, David J, Traub, Linton M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biochemistry/Cell Signaling and Trafficking Structures Bioengineering Biology Bowing Carrier Proteins - chemistry Carrier Proteins - metabolism Cell adhesion & migration Cell Biology/Membranes and Sorting Cell division Cell Movement - drug effects Chemokines Danio rerio Developmental Biology/Morphogenesis and Cell Biology Drosophila Ectopic expression Embryo, Nonmammalian - abnormalities Embryo, Nonmammalian - pathology Embryo, Nonmammalian - ultrastructure Embryogenesis Embryonic development Embryonic Development - drug effects Embryonic growth stage Embryos Endocytosis Gene expression Genetic aspects Genomes HeLa Cells Humans Insects Ligands Liposomes - metabolism Medical research Medicine Molecular Sequence Data Morphogenesis Notochord Notochord - abnormalities Notochord - drug effects Notochord - embryology Notochord - pathology Oligonucleotides, Antisense - pharmacology Phenotype Phosphoinositides Physiology Protein Binding - drug effects Protein Structure, Tertiary Proteins Scaffolds Signal transduction Structure-Activity Relationship Zebrafish Zebrafish - embryology Zebrafish Proteins - chemistry Zebrafish Proteins - metabolism
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