Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements

Alternative splicing controls the activity of many proteins important for neuronal excitation, but the signal-transduction pathways that affect spliced isoform expression are not well understood. One particularly interesting system of alternative splicing is exon 21 (E21) of the NMDA receptor 1 (NMD...

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Veröffentlicht in:	PLoS biology 2007-02, Vol.5 (2), p.e40
Hauptverfasser:	Lee, Ji-Ann, Xing, Yi, Nguyen, David, Xie, Jiuyong, Lee, Christopher J, Black, Douglas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Base Sequence Biochemistry Calcium-Calmodulin-Dependent Protein Kinase Type 4 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Computational Biology Consensus Sequence Exons Gene expression Genome Humans In Vitro Kinases Methyl aspartate Mice Molecular Biology Mutagenesis, Site-Directed Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - enzymology Neurons - metabolism Neurons - physiology Neuroscience Proteins Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Regulation Regulatory Sequences, Ribonucleic Acid Reverse Transcriptase Polymerase Chain Reaction RNA Precursors - metabolism RNA splicing Signal Transduction
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