Assessing the contribution of heme-iron acquisition to Staphylococcus aureus pneumonia using computed tomography

S. aureus acquires heme-iron using the iron regulated surface determinant (Isd) system and the heme transport system (Hts) with both systems showing critical importance in systemic models of infection. The contribution of heme-iron acquisition to staphylococcal pneumonia has not yet been elucidated....

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Veröffentlicht in:	PloS one 2009-08, Vol.4 (8), p.e6668-e6668
Hauptverfasser:	Mason, William Jeffrey, Skaar, Eric Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bacteria CAT scans Computation Computed tomography Development and progression Disease Models, Animal Drug dosages Experiments Gram-positive bacteria Heme Heme - metabolism Hemoglobin Histology Imaging Infections Infectious Diseases/Bacterial Infections Infectious Diseases/Nosocomial and Healthcare-Associated Infections Infectious Diseases/Respiratory Infections Iron Kidneys Laboratories Lungs Medical imaging Metabolism Mice Mice, Inbred BALB C Microbiology Microbiology/Medical Microbiology Microbiology/Microbial Evolution and Genomics Microbiology/Microbial Growth and Development Microbiology/Microbial Physiology and Metabolism Molecular Biology Mortality Mutagenesis Pasteurella Pathogenesis Pneumonia Pneumonia, Bacterial - diagnostic imaging Pneumonia, Bacterial - metabolism Pneumonia, Bacterial - microbiology Proteins Public Health and Epidemiology/Infectious Diseases Significance Staphylococcal infections Staphylococcus aureus Staphylococcus aureus - isolation & purification Staphylococcus aureus - pathogenicity Staphylococcus infections Statistical analysis Statistical significance Strains (organisms) Tomography Tomography, X-Ray Computed Virulence
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