MMP7 Shedding of Syndecan-1 Facilitates Re-Epithelialization by Affecting α2β1 Integrin Activation

Background Lung injury promotes the expression of matrix metalloproteinase-7 (MMP7, matrilysin), which is required for neutrophil recruitment and re-epithelialization. MMP7 governs the lung inflammatory response through the shedding of syndecan-1. Because inflammation and repair are related events,...

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Veröffentlicht in:	PloS one 2009-08, Vol.4 (8), p.e6565
Hauptverfasser:	Chen, Peter, Abacherli, Laura E., Nadler, Samuel T., Wang, Ying, Li, Qinglang, Parks, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis Cell adhesion Cell adhesion & migration Cell Biology Cell Biology/Cell Adhesion Cell Biology/Extra-Cellular Matrix Cell migration Collagen Conformation Epithelium Fibroblasts Heparan sulfate Inflammation Inflammatory response Leukocyte migration Ligands Lungs Matrilysin Matrix metalloproteinase Medicine Metalloproteinase Microscopy Molecular biology Phosphorylation Recruitment Repair Rodents Shedding Syndecan Thrombosis Wound healing Wounds
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