The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

In Alternative Lengthening of Telomeres (ALT) cell lines, specific nuclear bodies called APBs (ALT-associated PML bodies) concentrate telomeric DNA, shelterin components and recombination factors associated with telomere recombination. Topoisomerase IIIα (Topo III) is an essential telomeric-associat...

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Veröffentlicht in:	PloS one 2009-09, Vol.4 (9), p.e6919
Hauptverfasser:	Temime-Smaali, Nassima, Guittat, Lionel, Sidibe, Assitan, Shin-ya, Kazuo, Trentesaux, Chantal, Riou, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Biochemistry/ and Repair Biochemistry/Chemical Biology of the Cell Breast cancer Cell division Cell growth Cell lines Deoxyribonucleic acid Disruption DNA DNA damage DNA topoisomerase III Forming Genes Genomes Intermediates Ligands Molecular Biology/Chromosome Structure Molecular Biology/DNA Oligonucleotides Pharmacology Pharmacology/Drug Development Proteins Recombination Senescence Telomerase Telomere-binding protein Telomeres TRF2 protein
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