A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis

Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in drug-resistant cancer cells. Aimed to determine the role of GCS in tumor response to chemotherapy, a new mixed-backbone oligonucleotide (MBO-...

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Veröffentlicht in:	PloS one 2009-09, Vol.4 (9), p.e6938
Hauptverfasser:	Patwardhan, Gauri A, Zhang, Qian-Jin, Yin, Dongmei, Gupta, Vineet, Bao, Jianxiong, Senkal, Can E, Ogretmen, Besim, Cabot, Myles C, Shah, Girish V, Sylvester, Paul W, Jazwinski, S Michal, Liu, Yong-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal tissues Animals Anthracyclines Antineoplastic drugs Apoptosis Backbone Biochemistry Biochemistry/Drug Discovery Biocompatibility Breast cancer Cancer Cancer therapies Caspase Cell Biology/Cellular Death and Stress Responses Cell Biology/Gene Expression Cell Line, Tumor Cell Survival Ceramide Ceramide glucosyltransferase Chemical compounds Chemotherapy Doxorubicin Drug resistance Drug Resistance, Neoplasm Enzymatic activity Enzyme activity Enzymes Female Gene expression Gene Expression Regulation, Neoplastic Glucosyltransferases - antagonists & inhibitors Glucosyltransferases - genetics Glycosylation Growth factors Health aspects Health sciences Humans In vivo methods and tests Kidney - metabolism Kidneys Kinases Liver Liver - metabolism Management buyouts Melanoma Mice Mice, Nude Microbial drug resistance Molecular biology Molecular Biology/Translational Regulation Multidrug resistance Multidrug resistant organisms Neoplasm Transplantation Oligonucleotides Oligonucleotides - pharmacology Oncology/Breast Cancer Oncology/Oncology Agents Ovarian cancer Pharmaceutical sciences Pharmacology Pharmacology/Drug Resistance Prostate cancer Proteins Silence Toxicity Tumor necrosis factor-TNF Tumors Xenografts
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