Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis

The dynamics of SNARE assembly and disassembly during membrane recognition and fusion is a central issue in intracellular trafficking and regulated secretion. Exocytosis of sperm's single vesicle--the acrosome--is a synchronized, all-or-nothing process that happens only once in the life of the...

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Veröffentlicht in:	PLoS biology 2005-10, Vol.3 (10), p.e323
Hauptverfasser:	De Blas, Gerardo A, Roggero, Carlos M, Tomes, Claudia N, Mayorga, Luis S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome - physiology Acrosome Reaction - physiology Botulinum Toxins - pharmacology Botulinum Toxins, Type A Calcimycin - pharmacology Calcium - metabolism Calcium - pharmacology Chelating Agents - pharmacology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Ethylenediamines - pharmacology Exocytosis - physiology Experiments Fluorescent Antibody Technique Humans In Vitro Male Membranes Neuroscience Permeability - drug effects Protein Structure, Quaternary - drug effects Proteins rab3A GTP-Binding Protein - physiology SNARE Proteins - metabolism Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins - metabolism Sperm Spermatozoa - drug effects Spermatozoa - metabolism Synaptosomal-Associated Protein 25 - metabolism Synaptotagmins - physiology Tetanus Tetanus Toxin - pharmacology Vesicle-Associated Membrane Protein 2 - metabolism
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