Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses

Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined. Both ends of the tetherin molecule are associated with the plasma membrane and it forms a homodimer. Therefore...

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Veröffentlicht in:	PloS one 2009-09, Vol.4 (9), p.e6934-e6934
Hauptverfasser:	Sakuma, Toshie, Sakurai, Akira, Yasuda, Jiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, CD - chemistry Antiviral activity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology B cells Bone marrow Cell growth Cell Membrane - metabolism Cell Membrane - virology Cell surface Cercopithecus aethiops Chemical bonds Cloning COS Cells Dimerization Disulfides Ebola virus Filoviridae Forensic sciences Glycoproteins GPI-Linked Proteins Humans Lassa virus - metabolism Marburg virus disease Marburgvirus - metabolism Membrane Glycoproteins - chemistry Models, Biological Multiple myeloma Mutants Mutation Offspring Particle production Plasmids - metabolism Progeny Proteins Viral infections Virion - metabolism Virions Virology Virology/Emerging Viral Diseases Virology/Host Antiviral Responses Virology/Virion Structure, Assembly, and Egress Viruses
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