A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury

Inflammation may lead to tissue injury. We have studied the modulation of inflammatory milieu-induced tissue injury, as exemplified by the mesothelium. Peritoneal dialysis is complicated by peritonitis episodes that cause loss of mesothelium. Proinflammatory cytokines are increased in the peritoneal...

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Veröffentlicht in:	PloS one 2009-08, Vol.4 (8), p.e6634-e6634
Hauptverfasser:	Santamaría, Beatriz, Benito-Martin, Alberto, Ucero, Alvaro Conrado, Aroeira, Luiz Stark, Reyero, Ana, Vicent, María Jesús, Orzáez, Mar, Celdrán, Angel, Esteban, Jaime, Selgas, Rafael, Ruíz-Ortega, Marta, Cabrera, Manuel López, Egido, Jesús, Pérez-Payá, Enrique, Ortiz, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apaf-1 protein Apoptosis Apoptotic Protease-Activating Factor 1 - physiology Bacterial infections Biochemistry/Drug Discovery Biological response modifiers Caspase Caspase-3 Caspase-8 Cell Biology/Cellular Death and Stress Responses Cell cycle Cell death Cells, Cultured Chemistry Cooperation Cytochrome Cytokines Cytokines - physiology Dialysis Effluents Epithelium Health aspects Humans Incubation Inflammation Inhibition Inhibitors Injuries Interferon Interferon gamma Laboratories Ligands Mesothelium Mice Modulation Mortality Nephrology/Dialysis and Renal Transplantation Omentum Pancreatic cancer Patients Peritoneal Dialysis Peritoneum Peritonitis Pharmaceutical sciences Recovery Regeneration Tumor necrosis factor-α Wound healing γ-Interferon
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