Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis

Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease. Vitamin D analogs like calcipotriol have antipsoriatic effects and might mediate this effect by changing AMP expression....

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Veröffentlicht in:	PloS one 2009-07, Vol.4 (7), p.e6340
Hauptverfasser:	Peric, Mark, Koglin, Sarah, Dombrowski, Yvonne, Gross, Katrin, Bradac, Eva, Büchau, Amanda, Steinmeyer, Andreas, Zügel, Ulrich, Ruzicka, Thomas, Schauber, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Anti-Infective Agents - metabolism Antiinfectives and antibacterials Antimicrobial Cationic Peptides - genetics Antimicrobial peptides Apoptosis Blotting, Western Calcipotriene Cells, Cultured Cytokines Dendritic cells Dermatology Dermatology/Psoriasis and Other Inflammatory Diseases Extracellular signal-regulated kinase Gene Expression Regulation - drug effects Genes, Reporter Humans Immunology/Innate Immunity Infectious diseases Inflammation Interleukin Interleukin 8 Interleukin-17 - genetics Interleukin-8 - genetics Interleukins Keratinocytes MAP Kinase Signaling System Medical treatment Neutrophils NF-κB protein Pathogenesis Peptides Peptides - genetics Peptides - metabolism Plaques Polymerase Chain Reaction Psoriasis Psoriasis - metabolism Receptors, Calcitriol - metabolism RNA Interference Signaling Skin Skin diseases Transcription Vitamin D Vitamin D - analogs & derivatives Vitamin D - pharmacology
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