Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

The mechanisms through which aberrant alpha-synuclein (ASYN) leads to neuronal death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes, mutant ASYNs impair Chaperone Mediated Autophagy (CMA), a targeted lysosomal degradation pathway; however, whether this occurs in a cellul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2009-05, Vol.4 (5), p.e5515
Hauptverfasser:	Xilouri, Maria, Vogiatzi, Tereza, Vekrellis, Kostas, Park, David, Stefanis, Leonidas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acidification Adenoviruses alpha-Synuclein - genetics alpha-Synuclein - metabolism alpha-Synuclein - toxicity Animals Apoptosis Autophagy Biodegradation Biomedical research Cell death Cell Line Cell lines Cell survival Degradation Disease Down-Regulation Humans Hypotheses Impairment Inhibition Liver Lysosomes Lysosomes - metabolism Molecular Chaperones - metabolism Mortality Movement disorders Mutation Neurodegenerative diseases Neurological Disorders Neurological Disorders/Movement Disorders Neurons Neurons - metabolism Neuroscience Neuroscience/Neurobiology of Disease and Regeneration Neurosciences Neurotoxicity Overexpression Parkinson Disease - metabolism Parkinson's disease PC12 Cells Phagocytosis Pheochromocytoma cells Proteins Rats RNA, Small Interfering - metabolism Rodents Synuclein Toxicity Trends
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!