CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population

The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory act...

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Veröffentlicht in:	PloS one 2009-07, Vol.4 (7), p.e6307-e6307
Hauptverfasser:	Thye, Thorsten, Scarisbrick, Genevieve, Browne, Edmund N L, Chinbuah, Margaret Amanua, Gyapong, John, Osei, Ivy, Owusu-Dabo, Ellis, Niemann, Stefan, Rüsch-Gerdes, Sabine, Meyer, Christian G, Horstmann, Rolf D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antigens Antigens, CD - immunology Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmunity Base Sequence Case-Control Studies Community CTLA-4 Antigen CTLA-4 protein Cytokines Cytotoxicity DNA Primers Gene frequency Genes Genetic aspects Genetics and Genomics/Genetics of Disease Genotype Ghana Haplotypes Health services Hepatitis Human immunodeficiency virus Humans Infections Infectious Diseases/Respiratory Infections Lymphocytes Lymphocytes T Medical research Medicine Minority & ethnic groups Mycobacterium Pathogens Phosphorylation Polymorphism Polymorphism, Single Nucleotide Pulmonary tuberculosis Radiographs Radiography Radiology and Medical Imaging Single nucleotide polymorphisms Single-nucleotide polymorphism Smear T cells Thyroid diseases Tuberculosis Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology
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