BMP receptor signaling is required for postnatal maintenance of articular cartilage

Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis. The molecular mechanisms that create and maintain this thin layer of cartilage that covers the surface of bones in joint regions are poorly understood,...

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Veröffentlicht in:	PLoS biology 2004-11, Vol.2 (11), p.e355-e355
Hauptverfasser:	Rountree, Ryan B, Schoor, Michael, Chen, Hao, Marks, Melissa E, Harley, Vincent, Mishina, Yuji, Kingsley, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Apoptosis Arthritis Bone Morphogenetic Protein Receptors - metabolism Bone Morphogenetic Protein Receptors, Type I - genetics Bone Morphogenetic Proteins - genetics Cartilage Cartilage - metabolism Cartilage - pathology Cartilage, Articular - embryology Cartilage, Articular - growth & development Cartilage, Articular - metabolism Cell Biology Cell Proliferation Chromosomes, Artificial, Bacterial - metabolism Development Gene Expression Regulation, Developmental Genetic Variation Genetics/Genomics/Gene Therapy Growth Differentiation Factor 5 Inflammation Integrases - metabolism Joints - embryology Kinases Mice Mice, Inbred C57BL Mice, Transgenic Molecular Sequence Data Mus (Mouse) Mutation Osteoarthritis - metabolism Phenotype Proteins Recombination, Genetic Risk Factors Signal Transduction Synovial Membrane - embryology Time Factors
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