Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians
Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of...
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| creator | Mueller, Edith E Eder, Waltraud Mayr, Johannes A Paulweber, Bernhard Sperl, Wolfgang Horninger, Wolfgang Klocker, Helmut Kofler, Barbara |
| description | Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population.
The nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population.
Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent. |
| doi_str_mv | 10.1371/journal.pone.0006370 |
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The nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population.
Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0006370</identifier><identifier>PMID: 19636411</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antigens ; Apoptosis ; Base Sequence ; Biopsy ; Breast cancer ; Cancer ; Cancer research ; Deoxyribonucleic acid ; Development and progression ; Disease ; DNA ; DNA Primers ; DNA sequencing ; Enzymes ; Etiology ; European Continental Ancestry Group ; Gene sequencing ; Genetic aspects ; Genetic polymorphisms ; Genetics and Genomics/Cancer Genetics ; Genetics and Genomics/Population Genetics ; Genomes ; Genomics ; Haplotypes ; Health screening ; Humans ; Kidney cancer ; Leukocytes (mononuclear) ; Male ; Mitochondria ; Mitochondrial DNA ; Mortality ; Mutation ; Nucleotide sequence ; Oncology/Prostate Cancer ; Oxygen ; Patients ; Pediatrics ; Peripheral blood mononuclear cells ; Phosphorylation ; Polymorphism, Genetic ; Population ; Prostate ; Prostate cancer ; Prostate carcinoma ; Prostatic Neoplasms - ethnology ; Prostatic Neoplasms - genetics ; Reactive oxygen species ; Urology ; Urology/Prostate Cancer ; White people ; Whites</subject><ispartof>PloS one, 2009-07, Vol.4 (7), p.e6370-e6370</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Mueller et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Mueller et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c662t-417162704b9a4d293cf79b7b323a92aa525ec59c657dac051bb845f2f703f5e93</citedby><cites>FETCH-LOGICAL-c662t-417162704b9a4d293cf79b7b323a92aa525ec59c657dac051bb845f2f703f5e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712094/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712094/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19636411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vickers, Andrew</contributor><creatorcontrib>Mueller, Edith E</creatorcontrib><creatorcontrib>Eder, Waltraud</creatorcontrib><creatorcontrib>Mayr, Johannes A</creatorcontrib><creatorcontrib>Paulweber, Bernhard</creatorcontrib><creatorcontrib>Sperl, Wolfgang</creatorcontrib><creatorcontrib>Horninger, Wolfgang</creatorcontrib><creatorcontrib>Klocker, Helmut</creatorcontrib><creatorcontrib>Kofler, Barbara</creatorcontrib><title>Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population.
The nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population.
Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent.</description><subject>Analysis</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Base Sequence</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>Disease</subject><subject>DNA</subject><subject>DNA Primers</subject><subject>DNA sequencing</subject><subject>Enzymes</subject><subject>Etiology</subject><subject>European Continental Ancestry Group</subject><subject>Gene sequencing</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetics and Genomics/Cancer Genetics</subject><subject>Genetics and Genomics/Population Genetics</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Haplotypes</subject><subject>Health screening</subject><subject>Humans</subject><subject>Kidney cancer</subject><subject>Leukocytes (mononuclear)</subject><subject>Male</subject><subject>Mitochondria</subject><subject>Mitochondrial DNA</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Nucleotide sequence</subject><subject>Oncology/Prostate Cancer</subject><subject>Oxygen</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Peripheral blood mononuclear cells</subject><subject>Phosphorylation</subject><subject>Polymorphism, Genetic</subject><subject>Population</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostate carcinoma</subject><subject>Prostatic Neoplasms - ethnology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Reactive oxygen species</subject><subject>Urology</subject><subject>Urology/Prostate 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haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians</title><author>Mueller, Edith E ; Eder, Waltraud ; Mayr, Johannes A ; Paulweber, Bernhard ; Sperl, Wolfgang ; Horninger, Wolfgang ; Klocker, Helmut ; Kofler, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c662t-417162704b9a4d293cf79b7b323a92aa525ec59c657dac051bb845f2f703f5e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Base Sequence</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>Disease</topic><topic>DNA</topic><topic>DNA Primers</topic><topic>DNA sequencing</topic><topic>Enzymes</topic><topic>Etiology</topic><topic>European 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One</addtitle><date>2009-07-28</date><risdate>2009</risdate><volume>4</volume><issue>7</issue><spage>e6370</spage><epage>e6370</epage><pages>e6370-e6370</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population.
The nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population.
Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19636411</pmid><doi>10.1371/journal.pone.0006370</doi><tpages>e6370</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Antigens Apoptosis Base Sequence Biopsy Breast cancer Cancer Cancer research Deoxyribonucleic acid Development and progression Disease DNA DNA Primers DNA sequencing Enzymes Etiology European Continental Ancestry Group Gene sequencing Genetic aspects Genetic polymorphisms Genetics and Genomics/Cancer Genetics Genetics and Genomics/Population Genetics Genomes Genomics Haplotypes Health screening Humans Kidney cancer Leukocytes (mononuclear) Male Mitochondria Mitochondrial DNA Mortality Mutation Nucleotide sequence Oncology/Prostate Cancer Oxygen Patients Pediatrics Peripheral blood mononuclear cells Phosphorylation Polymorphism, Genetic Population Prostate Prostate cancer Prostate carcinoma Prostatic Neoplasms - ethnology Prostatic Neoplasms - genetics Reactive oxygen species Urology Urology/Prostate Cancer White people Whites |
| title | Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians |
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