HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase lentiviral replication in the host, yet the mechanisms underlying these effects have remained elusive. Since...

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Veröffentlicht in:	PLoS biology 2004-01, Vol.2 (1), p.E6-E6
Hauptverfasser:	Janardhan, Ajit, Swigut, Tomek, Hill, Brian, Myers, Michael P, Skowronski, Jacek
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism CD28 Antigens - biosynthesis CD3 Complex - biosynthesis Cell adhesion & migration Cell Biology Cell Movement Chemokines Chemotaxis Epitopes - chemistry Experiments Gene Products, nef - metabolism Gene Products, nef - physiology GTPase-Activating Proteins Guanine Nucleotide Exchange Factors - metabolism HIV-1 - metabolism Homo (Human) Human immunodeficiency virus 1 Humans Immune system Infectious Diseases Interleukin-2 - metabolism Jurkat Cells Lentivirus Lentivirus - genetics Lymphocytes Lymphocytes - cytology Lymphocytes - virology Mass Spectrometry - methods Medical research nef Gene Products, Human Immunodeficiency Virus Nef protein Plasmids - metabolism Polypeptides Protein Binding Proteins Proteomics - methods rac GTP-Binding Proteins - chemistry rac GTP-Binding Proteins - metabolism Rac protein rac1 GTP-Binding Protein - chemistry RAC2 GTP-Binding Protein Signal Transduction Spectrum analysis Virology Viruses
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