Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution

Human noroviruses are the major viral pathogens of epidemic acute gastroenteritis. These genetically diverse viruses comprise two major genogroups (GI and GII) and approximately 30 genotypes. Noroviruses recognize human histo-blood group antigens (HBGAs) in a diverse, strain-specific manner. Recentl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2009-04, Vol.4 (4), p.e5058-e5058
Hauptverfasser:	Tan, Ming, Xia, Ming, Chen, Yutao, Bu, Weiming, Hegde, Rashmi S, Meller, Jarek, Li, Xuemei, Jiang, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Analysis Antigens Base Sequence Binding Sites Biological Evolution Biophysics Blood Group Antigens - metabolism Blood groups Carbohydrate Metabolism Carbohydrates Children & youth Conservation Convergence Crystal structure Developmental biology Disease transmission Divergence DNA Primers Epidemics Evolution Evolution & development Evolutionary Biology Functional analysis Gastroenteritis Genes Genotypes Health aspects Hospitals Humans Infection Infectious diseases Infectious Diseases/Gastrointestinal Infections Interfaces Laboratories Ligands Medicine Models, Molecular Molecular Sequence Data Mutagenesis Natural selection Norovirus Norovirus - genetics Norwalk virus Pediatrics Phylogenetics Proteins Receptors Sequence Homology, Amino Acid Site-directed mutagenesis Strains (organisms) Target acquisition Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virology Virology/Virion Structure, Assembly, and Egress Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!