Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

Tumor associated fibroblasts (TAF), are essential for tumor progression providing both a functional and structural supportive environment. TAF, known as activated fibroblasts, have an established biological impact on tumorigenesis as matrix synthesizing or matrix degrading cells, contractile cells,...

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Veröffentlicht in:	PloS one 2009-04, Vol.4 (4), p.e4992-e4992
Hauptverfasser:	Spaeth, Erika L, Dembinski, Jennifer L, Sasser, A Kate, Watson, Keri, Klopp, Ann, Hall, Brett, Andreeff, Michael, Marini, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adenocarcinoma Analysis Angiogenesis Animal models Animals Bone marrow Brain cancer Breast cancer Cancer Cell Biology Cell Division Cell Lineage Cell proliferation Chemokines Cytokines Desmin Development and progression Disease Progression Enzymes Epidermal growth factor Epidermal growth factors Female Fibroblasts Fibroblasts - cytology Gene expression Growth factors Hematology Hepatocyte growth factor Humans Immunomodulation Interleukin Interleukin 6 Interleukins Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Metastasis Motility Muscle contraction Muscle proteins Neovascularization Oncology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - pathology Pancreas Paracrine signalling Pathology Pediatrics Population Prostate cancer Proteins Recruitment Rodents Smooth muscle Stem cell transplantation Stem cells Stromelysin Transplantation, Heterologous Tumors Vascular endothelial growth factor Xenografts
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