CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction

Background The linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease. To this end, we previously demonstrated that transgenic over-expression of CCL2 enhanced micro...

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Veröffentlicht in:	PloS one 2009-07, Vol.4 (7), p.e6197
Hauptverfasser:	Kiyota, Tomomi, Yamamoto, Masaru, Xiong, Huangui, Lambert, Mary P., Klein, William L., Gendelman, Howard E., Ransohoff, Richard M., Ikezu, Tsuneya
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid precursor protein Brain Cognition Cognition & reasoning Computer memory Hippocampus Inflammation Linkages Mice Microglia Monocyte chemoattractant protein 1 Neurodegeneration Neurodegenerative diseases Neurological Disorders/Alzheimer Disease Neurological Disorders/Cognitive Neurology and Dementia Neuroscience/Animal Cognition Neuroscience/Behavioral Neuroscience Neurosciences Oligomerization Oligomers Overexpression Pathogenesis Protein seeding Proteins Rodents Short term memory Spatial memory Synaptic transmission Tumor necrosis factor-α β-Amyloid
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