Uncovering the genetic landscape for multiple sleep-wake traits

Despite decades of research in defining sleep-wake properties in mammals, little is known about the nature or identity of genes that regulate sleep, a fundamental behaviour that in humans occupies about one-third of the entire lifespan. While genome-wide association studies in humans and quantitativ...

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Veröffentlicht in:	PloS one 2009-04, Vol.4 (4), p.e5161-e5161
Hauptverfasser:	Winrow, Christopher J, Williams, Deanna L, Kasarskis, Andrew, Millstein, Joshua, Laposky, Aaron D, Yang, He S, Mrazek, Karrie, Zhou, Lili, Owens, Joseph R, Radzicki, Daniel, Preuss, Fabian, Schadt, Eric E, Shimomura, Kazuhiro, Vitaterna, Martha H, Zhang, Chunsheng, Koblan, Kenneth S, Renger, John J, Turek, Fred W
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Animals Bayes Theorem Bayesian analysis Biology Chromosome 17 Chromosome Mapping Chromosomes, Mammalian Crosses, Genetic Electroencephalography Electromyography Emotional disorders Eye movements Factor Analysis, Statistical Gene mapping Genes Genetic control Genetic Linkage Genetic research Genetics Genetics and Genomics/Animal Genetics Genetics and Genomics/Complex Traits Genomes Genomics Laboratories Latency Life span Light emitting diodes Lod Score Male Mammals Mice Mice, Inbred BALB C Mice, Inbred Strains Models, Genetic Mutation Neuroscience Neuroscience/Behavioral Neuroscience Polymorphism, Single Nucleotide Population Population genetics Quantitative genetics Quantitative trait loci Quantitative Trait Loci - genetics Reaction Time Regulatory mechanisms (biology) Rodents Sleep Sleep - genetics Sleep and wakefulness Sleep, REM - genetics Time Factors Trends
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