The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk
Polymorphisms in the mitochondrial genome are hypothesized to be associated with risk of various diseases, including cancer. However, there has been conflicting evidence for associations between a common polymorphism in the mitochondrial genome (A10398G, G10398A in some prior reports) and breast can...
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| description | Polymorphisms in the mitochondrial genome are hypothesized to be associated with risk of various diseases, including cancer. However, there has been conflicting evidence for associations between a common polymorphism in the mitochondrial genome (A10398G, G10398A in some prior reports) and breast cancer risk. Reactive oxygen species, a by-product of mitochondrial energy production, can lead to oxidative stress and DNA damage in both the mitochondria and their cells. Alcohol consumption, which may also lead to oxidative stress, is associated with breast cancer risk. Therefore, we hypothesized that polymorphisms in the mitochondrial genome interact with alcohol consumption to alter breast cancer risk. We genotyped the A10398G polymorphism in a case-control study nested within the Nurses' Health Study (NHS, 1,561 cases, 2,209 controls). We observed an interaction between alcohol consumption (yes/no) and A10398G on breast cancer risk (p-int = 0.03). The risk associated with alcohol consumption was limited to carriers of the 10398G allele (Odds Ratio 1.52, 95% Confidence Interval 1.10-2.08 comparing drinkers to non-drinkers). However, we were unable to replicate these findings in the Women's Health Study (WHS, 678 cases, 669 controls), although the power to detect this interaction in the WHS was low (power = 0.57). Further examination of this interaction, such as sufficiently powered epidemiological studies of cancer risk or associations with biomarkers of oxidative stress, may provide further evidence for GxE interactions between the A10398G mitochondrial polymorphism and alcohol consumption on breast cancer risk. |
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However, there has been conflicting evidence for associations between a common polymorphism in the mitochondrial genome (A10398G, G10398A in some prior reports) and breast cancer risk. Reactive oxygen species, a by-product of mitochondrial energy production, can lead to oxidative stress and DNA damage in both the mitochondria and their cells. Alcohol consumption, which may also lead to oxidative stress, is associated with breast cancer risk. Therefore, we hypothesized that polymorphisms in the mitochondrial genome interact with alcohol consumption to alter breast cancer risk. We genotyped the A10398G polymorphism in a case-control study nested within the Nurses' Health Study (NHS, 1,561 cases, 2,209 controls). We observed an interaction between alcohol consumption (yes/no) and A10398G on breast cancer risk (p-int = 0.03). The risk associated with alcohol consumption was limited to carriers of the 10398G allele (Odds Ratio 1.52, 95% Confidence Interval 1.10-2.08 comparing drinkers to non-drinkers). However, we were unable to replicate these findings in the Women's Health Study (WHS, 678 cases, 669 controls), although the power to detect this interaction in the WHS was low (power = 0.57). Further examination of this interaction, such as sufficiently powered epidemiological studies of cancer risk or associations with biomarkers of oxidative stress, may provide further evidence for GxE interactions between the A10398G mitochondrial polymorphism and alcohol consumption on breast cancer risk.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0005356</identifier><identifier>PMID: 19390621</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African Americans ; Aged ; Alcohol Drinking - genetics ; Alcohol use ; Alcoholic beverages ; Alzheimer's disease ; Amyotrophic lateral sclerosis ; Ataxia ; Bioindicators ; Biomarkers ; Breast cancer ; Breast Neoplasms - genetics ; Cancer ; Case-Control Studies ; Cell cycle ; Confidence intervals ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA, Mitochondrial - genetics ; Drinking of alcoholic beverages ; Epidemiology ; Ethanol ; Female ; Free radicals ; Genes ; Genetic aspects ; Genetics and Genomics/Cancer Genetics ; Genetics and Genomics/Complex Traits ; Genetics and Genomics/Genetics of Disease ; Genetics and Genomics/Population Genetics ; Genome, Mitochondrial - genetics ; Genomes ; Genomics ; Health aspects ; Health care ; Health risk assessment ; Health risks ; Hormone replacement therapy ; Hospitals ; Humans ; Laboratories ; Medical personnel ; Medical schools ; Middle Aged ; Mitochondria ; Nurses ; Oncology, Experimental ; Oncology/Breast Cancer ; Oxidative stress ; Oxidative Stress - genetics ; Oxygen ; Polymorphism ; Polymorphism, Genetic - genetics ; Public health ; Public Health and Epidemiology ; Reactive oxygen species ; Risk ; Risk Factors ; Women ; Womens health</subject><ispartof>PloS one, 2009-04, Vol.4 (4), p.e5356-e5356</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Pezzotti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Pezzotti et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-25881cbfabce84bcc808e527c175dd9eee80c61f0b231dace8725dc7075bf5b53</citedby><cites>FETCH-LOGICAL-c690t-25881cbfabce84bcc808e527c175dd9eee80c61f0b231dace8725dc7075bf5b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668794/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668794/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19390621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kronenberg, Florian</contributor><creatorcontrib>Pezzotti, Annamaria</creatorcontrib><creatorcontrib>Kraft, Peter</creatorcontrib><creatorcontrib>Hankinson, Susan E</creatorcontrib><creatorcontrib>Hunter, David J</creatorcontrib><creatorcontrib>Buring, Julie</creatorcontrib><creatorcontrib>Cox, David G</creatorcontrib><title>The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Polymorphisms in the mitochondrial genome are hypothesized to be associated with risk of various diseases, including cancer. However, there has been conflicting evidence for associations between a common polymorphism in the mitochondrial genome (A10398G, G10398A in some prior reports) and breast cancer risk. Reactive oxygen species, a by-product of mitochondrial energy production, can lead to oxidative stress and DNA damage in both the mitochondria and their cells. Alcohol consumption, which may also lead to oxidative stress, is associated with breast cancer risk. Therefore, we hypothesized that polymorphisms in the mitochondrial genome interact with alcohol consumption to alter breast cancer risk. We genotyped the A10398G polymorphism in a case-control study nested within the Nurses' Health Study (NHS, 1,561 cases, 2,209 controls). We observed an interaction between alcohol consumption (yes/no) and A10398G on breast cancer risk (p-int = 0.03). 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Further examination of this interaction, such as sufficiently powered epidemiological studies of cancer risk or associations with biomarkers of oxidative stress, may provide further evidence for GxE interactions between the A10398G mitochondrial polymorphism and alcohol consumption on breast cancer risk.</description><subject>African Americans</subject><subject>Aged</subject><subject>Alcohol Drinking - genetics</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alzheimer's disease</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Ataxia</subject><subject>Bioindicators</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cell cycle</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Drinking of alcoholic beverages</subject><subject>Epidemiology</subject><subject>Ethanol</subject><subject>Female</subject><subject>Free radicals</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetics and Genomics/Cancer Genetics</subject><subject>Genetics and Genomics/Complex Traits</subject><subject>Genetics and Genomics/Genetics of Disease</subject><subject>Genetics and Genomics/Population Genetics</subject><subject>Genome, Mitochondrial - 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However, there has been conflicting evidence for associations between a common polymorphism in the mitochondrial genome (A10398G, G10398A in some prior reports) and breast cancer risk. Reactive oxygen species, a by-product of mitochondrial energy production, can lead to oxidative stress and DNA damage in both the mitochondria and their cells. Alcohol consumption, which may also lead to oxidative stress, is associated with breast cancer risk. Therefore, we hypothesized that polymorphisms in the mitochondrial genome interact with alcohol consumption to alter breast cancer risk. We genotyped the A10398G polymorphism in a case-control study nested within the Nurses' Health Study (NHS, 1,561 cases, 2,209 controls). We observed an interaction between alcohol consumption (yes/no) and A10398G on breast cancer risk (p-int = 0.03). The risk associated with alcohol consumption was limited to carriers of the 10398G allele (Odds Ratio 1.52, 95% Confidence Interval 1.10-2.08 comparing drinkers to non-drinkers). However, we were unable to replicate these findings in the Women's Health Study (WHS, 678 cases, 669 controls), although the power to detect this interaction in the WHS was low (power = 0.57). Further examination of this interaction, such as sufficiently powered epidemiological studies of cancer risk or associations with biomarkers of oxidative stress, may provide further evidence for GxE interactions between the A10398G mitochondrial polymorphism and alcohol consumption on breast cancer risk.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19390621</pmid><doi>10.1371/journal.pone.0005356</doi><tpages>e5356</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2009-04, Vol.4 (4), p.e5356-e5356 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | African Americans Aged Alcohol Drinking - genetics Alcohol use Alcoholic beverages Alzheimer's disease Amyotrophic lateral sclerosis Ataxia Bioindicators Biomarkers Breast cancer Breast Neoplasms - genetics Cancer Case-Control Studies Cell cycle Confidence intervals Deoxyribonucleic acid DNA DNA damage DNA, Mitochondrial - genetics Drinking of alcoholic beverages Epidemiology Ethanol Female Free radicals Genes Genetic aspects Genetics and Genomics/Cancer Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Genetics of Disease Genetics and Genomics/Population Genetics Genome, Mitochondrial - genetics Genomes Genomics Health aspects Health care Health risk assessment Health risks Hormone replacement therapy Hospitals Humans Laboratories Medical personnel Medical schools Middle Aged Mitochondria Nurses Oncology, Experimental Oncology/Breast Cancer Oxidative stress Oxidative Stress - genetics Oxygen Polymorphism Polymorphism, Genetic - genetics Public health Public Health and Epidemiology Reactive oxygen species Risk Risk Factors Women Womens health |
| title | The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T23%3A43%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20mitochondrial%20A10398G%20polymorphism,%20interaction%20with%20alcohol%20consumption,%20and%20breast%20cancer%20risk&rft.jtitle=PloS%20one&rft.au=Pezzotti,%20Annamaria&rft.date=2009-04-24&rft.volume=4&rft.issue=4&rft.spage=e5356&rft.epage=e5356&rft.pages=e5356-e5356&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0005356&rft_dat=%3Cgale_plos_%3EA473198057%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1290546934&rft_id=info:pmid/19390621&rft_galeid=A473198057&rft_doaj_id=oai_doaj_org_article_d837db9eb43240c38d5089bdede3216e&rfr_iscdi=true |