Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells

DNA replication produces tangled, or catenated, chromatids, that must be decatenated prior to mitosis or catastrophic genomic damage will occur. Topoisomerase IIalpha (Topo IIalpha) is the primary decatenating enzyme. Cells monitor catenation status and activate decatenation checkpoints when decaten...

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Veröffentlicht in:	PloS one 2009-04, Vol.4 (4), p.e5323-e5323
Hauptverfasser:	Wray, Justin, Williamson, Elizabeth A, Royce, Melanie, Shaheen, Montaser, Beck, Brian D, Lee, Suk-Hee, Nickoloff, Jac A, Hromas, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracycline Anthracyclines Anthracyclines - pharmacology Antigens, Neoplasm - metabolism Apoptosis Biochemistry Biomarkers Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Cancer Cancer cells Catenation Cell cycle Cell Line, Tumor Chemotherapy Chromatids Deoxyribonucleic acid Development and progression DNA DNA biosynthesis DNA damage DNA repair DNA replication DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Drug resistance Drug Resistance, Neoplasm Drug therapy, Combination Enzyme Inhibitors - pharmacology Female Hematology Histone-Lysine N-Methyltransferase - metabolism Humans Inhibitors Kinases Medical research Medicine Metaphase Metastasis Mitosis Molecular biology Oncology Oncology/Breast Cancer Oncology/Oncology Agents Proteins Science Topoisomerase II Inhibitors
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