Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin

Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psoriasis susceptibi...

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Veröffentlicht in:	PloS one 2009-03, Vol.4 (3), p.e4725-e4725
Hauptverfasser:	Jansen, Patrick A M, Rodijk-Olthuis, Diana, Hollox, Edward J, Kamsteeg, Marijke, Tjabringa, Geuranne S, de Jongh, Gys J, van Vlijmen-Willems, Ivonne M J J, Bergboer, Judith G M, van Rossum, Michelle M, de Jong, Elke M G J, den Heijer, Martin, Evers, Andrea W M, Bergers, Mieke, Armour, John A L, Zeeuwen, Patrick L J M, Schalkwijk, Joost
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Adult Aged Antibiotics Antiinfectives and antibacterials Antimicrobial agents Arthritis Arthritis, Rheumatoid Atopic dermatitis beta-Defensins - blood Biomarkers Biomarkers - blood Celiac disease Chromosomes Copy number Cytokines Defensins Dendritic cells Dermatitis Dermatitis, Atopic - blood Dermatology Dermatology/Atopic Dermatitis and Other Forms of Eczema Dermatology/Psoriasis and Other Inflammatory Diseases Disease Disease control Eczema Epidermis Female Gene Dosage Genes Humans Immunoglobulins Immunology/Genetics of the Immune System Immunology/Innate Immunity Inflammation Life sciences Male Microbiology/Innate Immunity Middle Aged Patients Peptides Proteins Psoriasis Psoriasis - diagnosis Skin Skin - blood supply Skin diseases Trends
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