Human TRIM gene expression in response to interferons
Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunit...
Gespeichert in:
| Veröffentlicht in: | PloS one 2009-03, Vol.4 (3), p.e4894 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | e4894 |
| container_title | PloS one |
| container_volume | 4 |
| creator | Carthagena, Laetitia Bergamaschi, Anna Luna, Joseph M David, Annie Uchil, Pradeep D Margottin-Goguet, Florence Mothes, Walther Hazan, Uriel Transy, Catherine Pancino, Gianfranco Nisole, Sébastien |
| description | Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.
To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages.
Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities. |
| doi_str_mv | 10.1371/journal.pone.0004894 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1290299950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A473347380</galeid><doaj_id>oai_doaj_org_article_b41400da254040758c1fd396562a3da0</doaj_id><sourcerecordid>A473347380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c696t-2005e8d7f1f9eb963380354b589a912eb6f4cd69a317ed16d88e1d7b50dde5b93</originalsourceid><addsrcrecordid>eNqNkm2L1DAQx4so3nn6DUQLguCLXfPc5o2wHOourBycp29D2kx3u3SbvaQ9zm_v1FZvVxCkhGYmv_nPTDJJ8pKSOeUZfb_zfWhtMz_4FuaEEJFr8Sg5p5qzmWKEPz7anyXPYtwRInmu1NPkjGqmB-s8kct-b9v05nr1Jd1ACyncHwLEWPs2rdsUt6gfIe08mh2ECgLaz5MnlW0ivJj-F8m3Tx9vLpez9dXn1eViPSuVVt2MYQ7IXVbRSkOhFec54VIUMtdWUwaFqkTplLacZuCocnkO1GWFJM6BLDS_SF6PuofGRzN1HA3F6pnWWhIkViPhvN2ZQ6j3Nvww3tbml8OHjbGhq8sGTCGoIMRZJgURJJN5SSvHtZKKWe7soPVhytYXe3AltF2wzYno6Ulbb83G3xmmJGoLFHg3Cmz_Clsu1mbwEYYla8XuKLJvpmTB3_YQu3-0Nx-pjcUO6rbymLjEz8G-LvHlqxr9C5FxjisnDyVMAch0cN9tbB-jWX29_n_26vsp-_aI3YJtum30Td_hoMRTUIxgGXyMAao_F0GJGQb3d59mGFwzDS6GvTq--4egaVL5Twrv5o8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1290299950</pqid></control><display><type>article</type><title>Human TRIM gene expression in response to interferons</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Carthagena, Laetitia ; Bergamaschi, Anna ; Luna, Joseph M ; David, Annie ; Uchil, Pradeep D ; Margottin-Goguet, Florence ; Mothes, Walther ; Hazan, Uriel ; Transy, Catherine ; Pancino, Gianfranco ; Nisole, Sébastien</creator><contributor>Fritz, Jörg Hermann</contributor><creatorcontrib>Carthagena, Laetitia ; Bergamaschi, Anna ; Luna, Joseph M ; David, Annie ; Uchil, Pradeep D ; Margottin-Goguet, Florence ; Mothes, Walther ; Hazan, Uriel ; Transy, Catherine ; Pancino, Gianfranco ; Nisole, Sébastien ; Fritz, Jörg Hermann</creatorcontrib><description>Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.
To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages.
Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0004894</identifier><identifier>PMID: 19290053</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Antiviral activity ; Cell activation ; Classification ; Gene expression ; Gene Expression Regulation - drug effects ; Genes ; Genetic research ; HIV ; Human immunodeficiency virus ; Humans ; Immune response ; Immune system ; Immunity ; Immunology ; Immunotherapy ; Infections ; Innate immunity ; Interferon ; Interferons - pharmacology ; Life Sciences ; Lymphocytes ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Membrane Proteins - genetics ; Monocytes ; Pathogenesis ; Phylogeny ; Promoter Regions, Genetic ; Proteins ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription factors ; Viral infections ; Virology/Host Antiviral Responses ; Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics ; Virology/Viral and Gene Regulation ; Viruses</subject><ispartof>PloS one, 2009-03, Vol.4 (3), p.e4894</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Carthagena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>Carthagena et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c696t-2005e8d7f1f9eb963380354b589a912eb6f4cd69a317ed16d88e1d7b50dde5b93</citedby><cites>FETCH-LOGICAL-c696t-2005e8d7f1f9eb963380354b589a912eb6f4cd69a317ed16d88e1d7b50dde5b93</cites><orcidid>0000-0002-3124-6690 ; 0000-0001-9793-419X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654144/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654144/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19290053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02503962$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Fritz, Jörg Hermann</contributor><creatorcontrib>Carthagena, Laetitia</creatorcontrib><creatorcontrib>Bergamaschi, Anna</creatorcontrib><creatorcontrib>Luna, Joseph M</creatorcontrib><creatorcontrib>David, Annie</creatorcontrib><creatorcontrib>Uchil, Pradeep D</creatorcontrib><creatorcontrib>Margottin-Goguet, Florence</creatorcontrib><creatorcontrib>Mothes, Walther</creatorcontrib><creatorcontrib>Hazan, Uriel</creatorcontrib><creatorcontrib>Transy, Catherine</creatorcontrib><creatorcontrib>Pancino, Gianfranco</creatorcontrib><creatorcontrib>Nisole, Sébastien</creatorcontrib><title>Human TRIM gene expression in response to interferons</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.
To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages.
Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Antiviral activity</subject><subject>Cell activation</subject><subject>Classification</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes</subject><subject>Genetic research</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Infections</subject><subject>Innate immunity</subject><subject>Interferon</subject><subject>Interferons - pharmacology</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Monocytes</subject><subject>Pathogenesis</subject><subject>Phylogeny</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Transcription factors</subject><subject>Viral infections</subject><subject>Virology/Host Antiviral Responses</subject><subject>Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics</subject><subject>Virology/Viral and Gene Regulation</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkm2L1DAQx4so3nn6DUQLguCLXfPc5o2wHOourBycp29D2kx3u3SbvaQ9zm_v1FZvVxCkhGYmv_nPTDJJ8pKSOeUZfb_zfWhtMz_4FuaEEJFr8Sg5p5qzmWKEPz7anyXPYtwRInmu1NPkjGqmB-s8kct-b9v05nr1Jd1ACyncHwLEWPs2rdsUt6gfIe08mh2ECgLaz5MnlW0ivJj-F8m3Tx9vLpez9dXn1eViPSuVVt2MYQ7IXVbRSkOhFec54VIUMtdWUwaFqkTplLacZuCocnkO1GWFJM6BLDS_SF6PuofGRzN1HA3F6pnWWhIkViPhvN2ZQ6j3Nvww3tbml8OHjbGhq8sGTCGoIMRZJgURJJN5SSvHtZKKWe7soPVhytYXe3AltF2wzYno6Ulbb83G3xmmJGoLFHg3Cmz_Clsu1mbwEYYla8XuKLJvpmTB3_YQu3-0Nx-pjcUO6rbymLjEz8G-LvHlqxr9C5FxjisnDyVMAch0cN9tbB-jWX29_n_26vsp-_aI3YJtum30Td_hoMRTUIxgGXyMAao_F0GJGQb3d59mGFwzDS6GvTq--4egaVL5Twrv5o8</recordid><startdate>20090317</startdate><enddate>20090317</enddate><creator>Carthagena, Laetitia</creator><creator>Bergamaschi, Anna</creator><creator>Luna, Joseph M</creator><creator>David, Annie</creator><creator>Uchil, Pradeep D</creator><creator>Margottin-Goguet, Florence</creator><creator>Mothes, Walther</creator><creator>Hazan, Uriel</creator><creator>Transy, Catherine</creator><creator>Pancino, Gianfranco</creator><creator>Nisole, Sébastien</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3124-6690</orcidid><orcidid>https://orcid.org/0000-0001-9793-419X</orcidid></search><sort><creationdate>20090317</creationdate><title>Human TRIM gene expression in response to interferons</title><author>Carthagena, Laetitia ; Bergamaschi, Anna ; Luna, Joseph M ; David, Annie ; Uchil, Pradeep D ; Margottin-Goguet, Florence ; Mothes, Walther ; Hazan, Uriel ; Transy, Catherine ; Pancino, Gianfranco ; Nisole, Sébastien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c696t-2005e8d7f1f9eb963380354b589a912eb6f4cd69a317ed16d88e1d7b50dde5b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Antiviral activity</topic><topic>Cell activation</topic><topic>Classification</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes</topic><topic>Genetic research</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Infections</topic><topic>Innate immunity</topic><topic>Interferon</topic><topic>Interferons - pharmacology</topic><topic>Life Sciences</topic><topic>Lymphocytes</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Membrane Proteins - genetics</topic><topic>Monocytes</topic><topic>Pathogenesis</topic><topic>Phylogeny</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Transcription factors</topic><topic>Viral infections</topic><topic>Virology/Host Antiviral Responses</topic><topic>Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics</topic><topic>Virology/Viral and Gene Regulation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carthagena, Laetitia</creatorcontrib><creatorcontrib>Bergamaschi, Anna</creatorcontrib><creatorcontrib>Luna, Joseph M</creatorcontrib><creatorcontrib>David, Annie</creatorcontrib><creatorcontrib>Uchil, Pradeep D</creatorcontrib><creatorcontrib>Margottin-Goguet, Florence</creatorcontrib><creatorcontrib>Mothes, Walther</creatorcontrib><creatorcontrib>Hazan, Uriel</creatorcontrib><creatorcontrib>Transy, Catherine</creatorcontrib><creatorcontrib>Pancino, Gianfranco</creatorcontrib><creatorcontrib>Nisole, Sébastien</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carthagena, Laetitia</au><au>Bergamaschi, Anna</au><au>Luna, Joseph M</au><au>David, Annie</au><au>Uchil, Pradeep D</au><au>Margottin-Goguet, Florence</au><au>Mothes, Walther</au><au>Hazan, Uriel</au><au>Transy, Catherine</au><au>Pancino, Gianfranco</au><au>Nisole, Sébastien</au><au>Fritz, Jörg Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human TRIM gene expression in response to interferons</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-03-17</date><risdate>2009</risdate><volume>4</volume><issue>3</issue><spage>e4894</spage><pages>e4894-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.
To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages.
Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19290053</pmid><doi>10.1371/journal.pone.0004894</doi><tpages>e4894</tpages><orcidid>https://orcid.org/0000-0002-3124-6690</orcidid><orcidid>https://orcid.org/0000-0001-9793-419X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2009-03, Vol.4 (3), p.e4894 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1290299950 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adaptor Proteins, Signal Transducing - genetics Antiviral activity Cell activation Classification Gene expression Gene Expression Regulation - drug effects Genes Genetic research HIV Human immunodeficiency virus Humans Immune response Immune system Immunity Immunology Immunotherapy Infections Innate immunity Interferon Interferons - pharmacology Life Sciences Lymphocytes Macrophages Macrophages - drug effects Macrophages - metabolism Membrane Proteins - genetics Monocytes Pathogenesis Phylogeny Promoter Regions, Genetic Proteins Reverse Transcriptase Polymerase Chain Reaction Transcription factors Viral infections Virology/Host Antiviral Responses Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics Virology/Viral and Gene Regulation Viruses |
| title | Human TRIM gene expression in response to interferons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T19%3A19%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20TRIM%20gene%20expression%20in%20response%20to%20interferons&rft.jtitle=PloS%20one&rft.au=Carthagena,%20Laetitia&rft.date=2009-03-17&rft.volume=4&rft.issue=3&rft.spage=e4894&rft.pages=e4894-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0004894&rft_dat=%3Cgale_plos_%3EA473347380%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1290299950&rft_id=info:pmid/19290053&rft_galeid=A473347380&rft_doaj_id=oai_doaj_org_article_b41400da254040758c1fd396562a3da0&rfr_iscdi=true |