Cysteine Redox Potential Determines Pro-Inflammatory IL-1β Levels

Background Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (Eh) of Cys/CySS is centered at approximately −80 mV in the plasma of healthy adults, and oxidation of Eh Cys/CySS is implicated in inflammation ass...

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Veröffentlicht in:	PloS one 2009-03, Vol.4 (3), p.e5017
Hauptverfasser:	Iyer, Smita S., Accardi, Carolyn J., Ziegler, Thomas R., Blanco, Roberto A., Ritzenthaler, Jeffrey D., Rojas, Mauricio, Roman, Jesse, Jones, Dean P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Amino acids Biochemistry Biomarkers Blood plasma Body mass Control systems Critical care Critical Care and Emergency Medicine/Sepsis and Multiple Organ Failure Cysteine Cystine Cytokines Diabetes Diet Dietary supplements Disease control Electrode potentials Endocrinology Health sciences IL-1β Immunology/Immunomodulation Immunology/Innate Immunity Inflammatory diseases Interleukins Laboratories Lipids Lipopolysaccharides Macular degeneration Medicine Metabolism Metabolites Mice Monocytes Nutrition Nutrition research Oxidation Physiology Plasmas (physics) Preservation Protein synthesis Proteins Redox potential Rodents Sepsis Sulfur Tumor necrosis factor-TNF
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