Upregulation of α7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides

Background The alpha-7 nicotinic acetylcholine receptor (α7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as Alzheimer's disease. Previous research implied t...

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Veröffentlicht in:	PloS one 2009-03, Vol.4 (3), p.e4846
Hauptverfasser:	Bond, Cherie E., Zimmermann, Martina, Greenfield, Susan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Acetylcholinesterase Alzheimer's disease Amino acids Apoptosis Binding Biochemistry/Cell Signaling and Trafficking Structures Biochemistry/Transcription and Translation Brain Bungarotoxin C-Terminus Calcium Cell Biology/Gene Expression Cell Biology/Neuronal Signaling Mechanisms Choline Excitotoxicity Gene expression Ligands Membrane trafficking Molecular Biology mRNA Neurodegeneration Neurodegenerative diseases Neurons Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neuronal Signaling Mechanisms Nicotine Peptides Pharmacology Phosphorylation Protein transport Proteins Receptors Transgenic animals Up-regulation
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