Phagocytic superoxide specifically damages an extracytoplasmic target to inhibit or kill Salmonella

The phagocytic oxidative burst is a primary effector of innate immunity that protects against bacterial infection. However, the mechanism by which reactive oxygen species (ROS) kill or inhibit bacteria is not known. It is often assumed that DNA is a primary target of oxidative damage, consistent wit...

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Veröffentlicht in:	PloS one 2009-03, Vol.4 (3), p.e4975
Hauptverfasser:	Craig, Maureen, Slauch, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibiotics Bacteria Bacterial diseases Bacterial infections Base excision repair Cell survival Copper Cytoplasm Damage Defects Deoxyribonucleic acid DNA DNA Repair E coli Enzymes Escherichia coli Granulocytes Health aspects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Hydrogen peroxide Immunity Infection Infections Innate immunity Laboratories Macrophages Macrophages - cytology Macrophages - microbiology Macrophages - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microbiology Microbiology/Innate Immunity Microbiology/Microbial Physiology and Metabolism Mutation Neutrophils Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitrogen Oxygen Pathogens Phagocytes Phagocytes - metabolism Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Rec A Recombinases - genetics Rec A Recombinases - metabolism RecA protein Recombination Recombination, Genetic Repair Respiratory Burst - physiology Salmonella Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity Sulfur Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxides Superoxides - metabolism Trends Virulence Virulence (Microbiology) Zinc Zinc compounds
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