Early adverse events, HPA activity and rostral anterior cingulate volume in MDD
Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to eval...
Gespeichert in:
| Veröffentlicht in: | PloS one 2009-03, Vol.4 (3), p.e4887-e4887 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e4887 |
|---|---|
| container_issue | 3 |
| container_start_page | e4887 |
| container_title | PloS one |
| container_volume | 4 |
| creator | Treadway, Michael T Grant, Merida M Ding, Zhaohua Hollon, Steven D Gore, John C Shelton, Richard C |
| description | Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.
Grey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.
These findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD. |
| doi_str_mv | 10.1371/journal.pone.0004887 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1290164042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A473335110</galeid><doaj_id>oai_doaj_org_article_2f446062d0c5411aa53d377e410e71b2</doaj_id><sourcerecordid>A473335110</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6437-1f3a01ead863e831f384c521bf29163e36d6855b896c91c28532b302189f3fd43</originalsourceid><addsrcrecordid>eNqNkluP0zAQhSMEYpeFf4AgEtJKK9HiWxznBanaC1tpURG3V8txJqkrNy62U7H_HpcGaBEPKA9xZr45zhydLHuO0RTTEr9ZucH3yk43rocpQogJUT7ITnFFyYQTRB8enE-yJyGsECqo4PxxdrJrFCVip9niWnl7n6tmCz5ADlvoY3id336Y5UpHszUxNfsm9y5Er2w6R_DG-VybvhusipBvnR3WkJs-f3919TR71Cob4Nn4Psu-3Fx_vryd3C3ezS9ndxPNGS0nuKUKYVCN4BQETZ-C6YLguiUVTiXKGy6KohYV1xXWRBSU1BQRLKqWtg2jZ9nLve7GuiBHL4LEpEKYM8RIIuZ7onFqJTferJW_l04Z-bPgfCeVj0ZbkKRljCNOGqQLhrFSBW1oWQLDCEpc77TejrcN9RoanUxKZhyJHnd6s5Sd20rCC85xmQTORwHvvg0QolyboMFa1YMbguQlEhSJ3V6v_gL_vdt0T3Uq_b7pW5du1elpYG10CkRrUn3GSkppgTFKAxdHA4mJ8D12aghBzj99_H928fWYPT9gl6BsXIaUh2hcH45Btgd1SlLw0P42DyO5y_OvPeUuz3LMcxp7cWj8n6ExwPQH3hDt7w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1290164042</pqid></control><display><type>article</type><title>Early adverse events, HPA activity and rostral anterior cingulate volume in MDD</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Treadway, Michael T ; Grant, Merida M ; Ding, Zhaohua ; Hollon, Steven D ; Gore, John C ; Shelton, Richard C</creator><contributor>Baune, Bernhard</contributor><creatorcontrib>Treadway, Michael T ; Grant, Merida M ; Ding, Zhaohua ; Hollon, Steven D ; Gore, John C ; Shelton, Richard C ; Baune, Bernhard</creatorcontrib><description>Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.
Grey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.
These findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0004887</identifier><identifier>PMID: 19325704</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Antidepressants ; Automation ; Brain research ; Case-Control Studies ; Children ; Cortisol ; Depression (Mood disorder) ; Depressive Disorder, Major - pathology ; Emotional disorders ; Glucocorticoids ; Gyrus Cinguli - pathology ; Humans ; Hydrocortisone - analysis ; Hydrocortisone - blood ; Hyperactivity ; Medical imaging ; Medical research ; Memory ; Mental depression ; Mental Health/Mood Disorders ; Mental Health/Psychology ; Mental Health/Psychopharmacology ; Meta-analysis ; Middle Aged ; Morphology ; Morphometry ; Nerve Fibers, Unmyelinated ; Neurobiology ; Organ Size ; Psychiatry ; Questioning ; Saliva - chemistry ; Substantia grisea ; Trauma ; Young Adult</subject><ispartof>PloS one, 2009-03, Vol.4 (3), p.e4887-e4887</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Treadway et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Treadway et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6437-1f3a01ead863e831f384c521bf29163e36d6855b896c91c28532b302189f3fd43</citedby><cites>FETCH-LOGICAL-c6437-1f3a01ead863e831f384c521bf29163e36d6855b896c91c28532b302189f3fd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656617/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656617/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23853,27911,27912,53778,53780,79357,79358</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19325704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Baune, Bernhard</contributor><creatorcontrib>Treadway, Michael T</creatorcontrib><creatorcontrib>Grant, Merida M</creatorcontrib><creatorcontrib>Ding, Zhaohua</creatorcontrib><creatorcontrib>Hollon, Steven D</creatorcontrib><creatorcontrib>Gore, John C</creatorcontrib><creatorcontrib>Shelton, Richard C</creatorcontrib><title>Early adverse events, HPA activity and rostral anterior cingulate volume in MDD</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.
Grey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.
These findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antidepressants</subject><subject>Automation</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Cortisol</subject><subject>Depression (Mood disorder)</subject><subject>Depressive Disorder, Major - pathology</subject><subject>Emotional disorders</subject><subject>Glucocorticoids</subject><subject>Gyrus Cinguli - pathology</subject><subject>Humans</subject><subject>Hydrocortisone - analysis</subject><subject>Hydrocortisone - blood</subject><subject>Hyperactivity</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Memory</subject><subject>Mental depression</subject><subject>Mental Health/Mood Disorders</subject><subject>Mental Health/Psychology</subject><subject>Mental Health/Psychopharmacology</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Morphometry</subject><subject>Nerve Fibers, Unmyelinated</subject><subject>Neurobiology</subject><subject>Organ Size</subject><subject>Psychiatry</subject><subject>Questioning</subject><subject>Saliva - chemistry</subject><subject>Substantia grisea</subject><subject>Trauma</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluP0zAQhSMEYpeFf4AgEtJKK9HiWxznBanaC1tpURG3V8txJqkrNy62U7H_HpcGaBEPKA9xZr45zhydLHuO0RTTEr9ZucH3yk43rocpQogJUT7ITnFFyYQTRB8enE-yJyGsECqo4PxxdrJrFCVip9niWnl7n6tmCz5ADlvoY3id336Y5UpHszUxNfsm9y5Er2w6R_DG-VybvhusipBvnR3WkJs-f3919TR71Cob4Nn4Psu-3Fx_vryd3C3ezS9ndxPNGS0nuKUKYVCN4BQETZ-C6YLguiUVTiXKGy6KohYV1xXWRBSU1BQRLKqWtg2jZ9nLve7GuiBHL4LEpEKYM8RIIuZ7onFqJTferJW_l04Z-bPgfCeVj0ZbkKRljCNOGqQLhrFSBW1oWQLDCEpc77TejrcN9RoanUxKZhyJHnd6s5Sd20rCC85xmQTORwHvvg0QolyboMFa1YMbguQlEhSJ3V6v_gL_vdt0T3Uq_b7pW5du1elpYG10CkRrUn3GSkppgTFKAxdHA4mJ8D12aghBzj99_H928fWYPT9gl6BsXIaUh2hcH45Btgd1SlLw0P42DyO5y_OvPeUuz3LMcxp7cWj8n6ExwPQH3hDt7w</recordid><startdate>20090326</startdate><enddate>20090326</enddate><creator>Treadway, Michael T</creator><creator>Grant, Merida M</creator><creator>Ding, Zhaohua</creator><creator>Hollon, Steven D</creator><creator>Gore, John C</creator><creator>Shelton, Richard C</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20090326</creationdate><title>Early adverse events, HPA activity and rostral anterior cingulate volume in MDD</title><author>Treadway, Michael T ; Grant, Merida M ; Ding, Zhaohua ; Hollon, Steven D ; Gore, John C ; Shelton, Richard C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6437-1f3a01ead863e831f384c521bf29163e36d6855b896c91c28532b302189f3fd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antidepressants</topic><topic>Automation</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Children</topic><topic>Cortisol</topic><topic>Depression (Mood disorder)</topic><topic>Depressive Disorder, Major - pathology</topic><topic>Emotional disorders</topic><topic>Glucocorticoids</topic><topic>Gyrus Cinguli - pathology</topic><topic>Humans</topic><topic>Hydrocortisone - analysis</topic><topic>Hydrocortisone - blood</topic><topic>Hyperactivity</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Memory</topic><topic>Mental depression</topic><topic>Mental Health/Mood Disorders</topic><topic>Mental Health/Psychology</topic><topic>Mental Health/Psychopharmacology</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Morphometry</topic><topic>Nerve Fibers, Unmyelinated</topic><topic>Neurobiology</topic><topic>Organ Size</topic><topic>Psychiatry</topic><topic>Questioning</topic><topic>Saliva - chemistry</topic><topic>Substantia grisea</topic><topic>Trauma</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Treadway, Michael T</creatorcontrib><creatorcontrib>Grant, Merida M</creatorcontrib><creatorcontrib>Ding, Zhaohua</creatorcontrib><creatorcontrib>Hollon, Steven D</creatorcontrib><creatorcontrib>Gore, John C</creatorcontrib><creatorcontrib>Shelton, Richard C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Treadway, Michael T</au><au>Grant, Merida M</au><au>Ding, Zhaohua</au><au>Hollon, Steven D</au><au>Gore, John C</au><au>Shelton, Richard C</au><au>Baune, Bernhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early adverse events, HPA activity and rostral anterior cingulate volume in MDD</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-03-26</date><risdate>2009</risdate><volume>4</volume><issue>3</issue><spage>e4887</spage><epage>e4887</epage><pages>e4887-e4887</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.
Grey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.
These findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19325704</pmid><doi>10.1371/journal.pone.0004887</doi><tpages>e4887</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2009-03, Vol.4 (3), p.e4887-e4887 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1290164042 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Antidepressants Automation Brain research Case-Control Studies Children Cortisol Depression (Mood disorder) Depressive Disorder, Major - pathology Emotional disorders Glucocorticoids Gyrus Cinguli - pathology Humans Hydrocortisone - analysis Hydrocortisone - blood Hyperactivity Medical imaging Medical research Memory Mental depression Mental Health/Mood Disorders Mental Health/Psychology Mental Health/Psychopharmacology Meta-analysis Middle Aged Morphology Morphometry Nerve Fibers, Unmyelinated Neurobiology Organ Size Psychiatry Questioning Saliva - chemistry Substantia grisea Trauma Young Adult |
| title | Early adverse events, HPA activity and rostral anterior cingulate volume in MDD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T10%3A59%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20adverse%20events,%20HPA%20activity%20and%20rostral%20anterior%20cingulate%20volume%20in%20MDD&rft.jtitle=PloS%20one&rft.au=Treadway,%20Michael%20T&rft.date=2009-03-26&rft.volume=4&rft.issue=3&rft.spage=e4887&rft.epage=e4887&rft.pages=e4887-e4887&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0004887&rft_dat=%3Cgale_plos_%3EA473335110%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1290164042&rft_id=info:pmid/19325704&rft_galeid=A473335110&rft_doaj_id=oai_doaj_org_article_2f446062d0c5411aa53d377e410e71b2&rfr_iscdi=true |