Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling

The majority of ovarian primordial follicles must be preserved in a quiescent state to allow for the regular production of gametes over the female reproductive lifespan. However, the molecular mechanism that maintains the long quiescence of primordial follicles is poorly understood. Under certain pa...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53810-e53810
Hauptverfasser:	Adhikari, Deepak, Risal, Sanjiv, Liu, Kui, Shen, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein Animals Biology Cell cycle Cell growth Chemotherapy Female Follicles Gametes Gene Expression Regulation, Developmental Germ Cells - growth & development Germ Cells - metabolism growth Homology Kinases Life span Mammals Mechanistic Target of Rapamycin Complex 1 Medicine Mice Molecular Biology Molekylärbiologi mouse ovary Multiprotein Complexes Mutation Oocytes Oocytes - drug effects Oocytes - growth & development Oocytes - metabolism Ovarian Follicle - drug effects Ovarian Follicle - growth & development Ovarian Follicle - metabolism ovarian toxicity ovotoxicity pathway Pharmacology Phosphatases Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Preservation Primary Ovarian Insufficiency - genetics Primary Ovarian Insufficiency - metabolism Primary Ovarian Insufficiency - physiopathology Proteins - antagonists & inhibitors Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - deficiency PTEN Phosphohydrolase - genetics PTEN protein Rapamycin Reproductive status Rodents Signal Transduction - drug effects Signaling Sirolimus - administration & dosage survival Tensin TOR protein TOR Serine-Threonine Kinases
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