Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity

Aberrant hypermethylation of CpG islands in housekeeping gene promoters and widespread genome hypomethylation are typical events occurring in cancer cells. The molecular mechanisms behind these cancer-related changes in DNA methylation patterns are not well understood. Two questions are particularly...

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Veröffentlicht in:	PloS one 2009-03, Vol.4 (3), p.e4717-e4717
Hauptverfasser:	Zampieri, Michele, Passananti, Claudio, Calabrese, Roberta, Perilli, Mariagrazia, Corbi, Nicoletta, De Cave, Fabiana, Guastafierro, Tiziana, Bacalini, Maria Giulia, Reale, Anna, Amicosante, Gianfranco, Calabrese, Lilia, Zlatanova, Jordanka, Caiafa, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adenosine diphosphate Animals Cancer Cancer prevention Cell Biology/Gene Expression Cell Line Chromatin CpG islands Demethylation Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA demethylase DNA Methylation Dnmt1 gene DNMT1 protein Enzymatic activity Epigenesis, Genetic Epigenetic inheritance Epigenetics Fibroblasts Gene expression Gene sequencing Gene silencing Genes Genetics and Genomics/Epigenetics Genome Genomes Genomics Glycoside Hydrolases - metabolism Hematology Immunoprecipitation Islands Medicine Methylation Methyltransferases Mice Molecular biology Molecular Biology/DNA Methylation Molecular modelling Monosaccharides Nucleotide sequence Overexpression Pathology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Poly(ADP-ribose) glycohydrolase Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Polymers Promoter Regions, Genetic Promoters Ribose Rodents Transcription (Genetics)
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