APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

Antineoplastic therapy may impair the survival of malignant cells to produce cell death. Consequently, direct measurement of tumor cell death in vivo is a highly desirable component of therapy response monitoring. We have previously shown that APOMAB representing the DAB4 clone of a La/SSB-specific...

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Veröffentlicht in:	PloS one 2009-02, Vol.4 (2), p.e4558
Hauptverfasser:	Al-Ejeh, Fares, Darby, Jocelyn M, Tsopelas, Chris, Smyth, Douglas, Manavis, Jim, Brown, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Activation Animal tissues Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacokinetics Antigens Antimitotic agents Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Arthritis Autoantibodies Autoimmunity Bearing Bioindicators Biomarkers Biotechnology Bone marrow Cancer Cancer therapies Caspase Caspase-3 Cell death Cell survival Chemotherapy Cleavage Correlation Cyclophosphamide Cyclophosphamide - pharmacology Cytotoxicity Damage accumulation Damage detection Death & dying Deoxyribonucleic acid Diagnostic systems DNA DNA Damage Etoposide Etoposide - pharmacology Fragments Gene expression Hospitals Human behavior Immunoglobulin G Immunohistochemistry Indium Ionizing radiation Laboratories Lymphoma Medical imaging Mice Mice, Inbred C57BL Monoclonal antibodies Mortality Non-Hodgkin's lymphomas Nuclear medicine Oncology Poly(ADP-ribose) polymerase Proteins Radiology and Medical Imaging/Radionuclide Imaging RNA polymerase Stem cells Survival Tissue Distribution Tumor cells Tumors
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