Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?

The pir multigene family, found in the genomes of Plasmodium vivax, P. knowlesi and the rodent malaria species, encode variant antigens that could be targets of the immune response. Individual parasites of the rodent malaria Plasmodium yoelii, selected by micromanipulation, transcribe only 1 to 3 di...

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Veröffentlicht in:	PloS one 2009-01, Vol.4 (1), p.e4285-e4285
Hauptverfasser:	Cunningham, Deirdre, Fonager, Jannik, Jarra, William, Carret, Celine, Preiser, Peter, Langhorne, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Biochemistry/Transcription and Translation Bioinformatics Chromosomes - genetics Clone Cells Cloning DNA microarrays Epigenesis, Genetic Epigenetic inheritance Epigenetics Erythrocytes Erythrocytes - parasitology Female Gene expression Gene Expression Profiling Gene Expression Regulation Gene regulation Genes Genes, Protozoan Genes, Switch Genetic aspects Genomes Genomics Immune response Immune system Immunodeficiency Immunology/Immunity to Infections Infections Infectious Diseases Infectious Diseases/Protozoal Infections Ligands Malaria Malaria - genetics Malaria - parasitology Male Medical research Memory Mice Mice, Inbred BALB C Microbiology/Parasitology Micromanipulation Multigene Family Oligonucleotide Array Sequence Analysis Parasites Parasitology Pir gene Plasmodium Plasmodium chabaudi Plasmodium falciparum Plasmodium yoelii - genetics Polymerase chain reaction Populations Proteins Protozoa Reverse Transcriptase Polymerase Chain Reaction Schizonts Schizonts - metabolism Studies Transcription Transcription (Genetics) Transcription, Genetic Trophozoites - metabolism Vector-borne diseases
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