The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression
The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transformi...
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| creator | Dupouy, Sandra Viardot-Foucault, Véronique Alifano, Marco Souazé, Frédérique Plu-Bureau, Geneviève Chaouat, Marc Lavaur, Anne Hugol, Danielle Gespach, Christian Gompel, Anne Forgez, Patricia |
| description | The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion.
we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients.
these data support the activation of neurotensinergic deleterious pathways in breast cancer progression. |
| doi_str_mv | 10.1371/journal.pone.0004223 |
| format | Article |
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we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients.
these data support the activation of neurotensinergic deleterious pathways in breast cancer progression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0004223</identifier><identifier>PMID: 19156213</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biopsy ; Breast cancer ; Breast carcinoma ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer ; Cancer therapies ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Cell Biology/Gene Expression ; Cell growth ; Dehydrogenases ; Development and progression ; Diabetes and Endocrinology/Multiple Endocrine Disorders and Neoplasias ; Disease Progression ; Estradiol - metabolism ; Estrogens ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Growth factors ; Humans ; Immunohistochemistry ; Invasiveness ; Kinases ; Lymph nodes ; Medical prognosis ; Metastases ; Middle Aged ; Neoplasm Invasiveness ; Neuropeptides ; Neurotensin ; Neurotrophin 1 ; Oligonucleotide Array Sequence Analysis ; Oncology/Breast Cancer ; Polymerase chain reaction ; Prognosis ; Receptors, Neurotensin - metabolism ; Rodents ; Tumors</subject><ispartof>PloS one, 2009-01, Vol.4 (1), p.e4223-e4223</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Dupouy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Dupouy et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c728t-1d4a1c7597273413e21d8396d5fe8f89cbfcb8944ae08e9521481f0da13b6ba03</citedby><cites>FETCH-LOGICAL-c728t-1d4a1c7597273413e21d8396d5fe8f89cbfcb8944ae08e9521481f0da13b6ba03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626627/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626627/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19156213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dupouy, Sandra</creatorcontrib><creatorcontrib>Viardot-Foucault, Véronique</creatorcontrib><creatorcontrib>Alifano, Marco</creatorcontrib><creatorcontrib>Souazé, Frédérique</creatorcontrib><creatorcontrib>Plu-Bureau, Geneviève</creatorcontrib><creatorcontrib>Chaouat, Marc</creatorcontrib><creatorcontrib>Lavaur, Anne</creatorcontrib><creatorcontrib>Hugol, Danielle</creatorcontrib><creatorcontrib>Gespach, Christian</creatorcontrib><creatorcontrib>Gompel, Anne</creatorcontrib><creatorcontrib>Forgez, Patricia</creatorcontrib><title>The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion.
we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients.
these data support the activation of neurotensinergic deleterious pathways in breast cancer progression.</description><subject>Aged</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast carcinoma</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Cell Biology/Gene Expression</subject><subject>Cell growth</subject><subject>Dehydrogenases</subject><subject>Development and progression</subject><subject>Diabetes and Endocrinology/Multiple Endocrine Disorders and Neoplasias</subject><subject>Disease Progression</subject><subject>Estradiol - metabolism</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Invasiveness</subject><subject>Kinases</subject><subject>Lymph nodes</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neuropeptides</subject><subject>Neurotensin</subject><subject>Neurotrophin 1</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology/Breast Cancer</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Receptors, Neurotensin - 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In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion.
we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients.
these data support the activation of neurotensinergic deleterious pathways in breast cancer progression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19156213</pmid><doi>10.1371/journal.pone.0004223</doi><tpages>e4223</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biopsy Breast cancer Breast carcinoma Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cell Biology/Gene Expression Cell growth Dehydrogenases Development and progression Diabetes and Endocrinology/Multiple Endocrine Disorders and Neoplasias Disease Progression Estradiol - metabolism Estrogens Female Gene expression Gene Expression Regulation, Neoplastic Growth factors Humans Immunohistochemistry Invasiveness Kinases Lymph nodes Medical prognosis Metastases Middle Aged Neoplasm Invasiveness Neuropeptides Neurotensin Neurotrophin 1 Oligonucleotide Array Sequence Analysis Oncology/Breast Cancer Polymerase chain reaction Prognosis Receptors, Neurotensin - metabolism Rodents Tumors |
| title | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression |
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