The internally truncated LRP5 receptor presents a therapeutic target in breast cancer

Breast cancer is a common malignant disease, which may be caused by a number of genes deregulated by genomic or epigenomic events. Deregulated WNT/beta-catenin signaling with accumulation of beta-catenin is common in breast tumors, but mutations in WNT signaling pathway components have been rare. An...

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Veröffentlicht in:	PloS one 2009-01, Vol.4 (1), p.e4243-e4243
Hauptverfasser:	Björklund, Peyman, Svedlund, Jessica, Olsson, Anna-Karin, Akerström, Göran, Westin, Gunnar
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Accumulation Analysis Animals Antibodies Apoptosis beta Catenin - metabolism Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - therapy Cancer Carcinoma - metabolism Cell Biology/Cell Signaling Cell Biology/Gene Expression Cell Line, Tumor Colorectal cancer Deregulation Development and progression Dkk1 protein Female Gene Expression Regulation, Neoplastic Health aspects Hospitals Humans Hyperparathyroidism Immunotherapy Inhibition LDL-Receptor Related Proteins - chemistry LDL-Receptor Related Proteins - metabolism LDL-Receptor Related Proteins - physiology Ligands Low Density Lipoprotein Receptor-Related Protein-5 LRP5 protein Mammary gland MEDICIN MEDICINE Metastases Metastasis Mice Mice, SCID Mutation Neoplasm Transplantation Neuroendocrine tumors Oncology/Breast Cancer Parathyroid Phosphorylation Receptors, LDL - metabolism Reverse transcription Signal transduction Stem cells Tumorigenesis Tumors Wnt protein Wnt Proteins - metabolism Wnt3 Protein Wnt3A Protein Xenografts β-Catenin
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