Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients

Fetal haemoglobin (HbF) is a major ameliorating factor in sickle cell disease. We investigated if a quantitative trait locus on chromosome 6q23 was significantly associated with HbF and F cell levels in individuals of African descent. Single nucleotide polymorphisms (SNPs) in a 24-kb intergenic regi...

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Veröffentlicht in:	PloS one 2009-01, Vol.4 (1), p.e4218-e4218
Hauptverfasser:	Creary, Lisa E, Ulug, Pinar, Menzel, Stephan, McKenzie, Colin A, Hanchard, Neil A, Taylor, Veronica, Farrall, Martin, Forrester, Terrence E, Thein, Swee Lay
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anemia, Sickle Cell - genetics Black People - genetics Blood & organ donations Blood pressure Blood transfusions Chromosome 6 Chromosomes Chromosomes, Human, Pair 6 College campuses Descent Enzymes Ethics Expatriates Fetal Hemoglobin - analysis Fetuses Gene loci Genes Genetic aspects Genetic diversity Genetic research Genetic Variation Genetics and Genomics/Complex Traits Genetics and Genomics/Genetics of Disease Genetics and Genomics/Population Genetics Haplotypes Hematology Hematology/Hemoglobinopathies Hemoglobin Hemoglobins Hospitals Humans Medical research Medicine Metabolism MYB gene Patients Polymorphism, Single Nucleotide Population studies Populations Quantitative genetics Quantitative trait loci Sickle cell anemia Sickle cell disease Single nucleotide polymorphisms Single-nucleotide polymorphism White People
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