Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner

DTNBP1 has been recognized as a schizophrenia susceptible gene, and its protein product, dysbindin-1, is down-regulated in the brains of schizophrenic patients. However, little is known about the physiological role of dysbindin-1 in the central nervous system. We hypothesized that disruption of dysb...

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Veröffentlicht in:	PloS one 2009-01, Vol.4 (1), p.e4199-e4199
Hauptverfasser:	Oyama, Satoko, Yamakawa, Hidekuni, Sasagawa, Noboru, Hosoi, Yoshio, Futai, Eugene, Ishiura, Shoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Cell Biology Cell Nucleus Central Nervous System Chromosomes Cytosol Deoxyribonucleic acid Disruption DNA DNA repair DNA-Activated Protein Kinase - metabolism DNA-dependent protein kinase Dysbindin Dystrophin-Associated Proteins Exons Genes Humans Introns Isoforms Kinases Life sciences Lymphocytes B Lysates Mass spectrometry Mental disorders Mental Health/Schizophrenia and Other Psychoses Microscopy Molecular Biology Musculoskeletal system Neuroblastoma Nuclei Pathogenesis Patients Phosphorylation Physiological aspects Polymorphism, Single Nucleotide Protein Isoforms - metabolism Protein kinase C Protein kinases Proteins Rodents Saccharomyces cerevisiae Schizophrenia Schizophrenia - etiology Scientific imaging Single nucleotide polymorphisms Single-nucleotide polymorphism Splicing Thyroid gland
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