Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation
As increasing numbers of older people are listed for solid organ transplantation, there is an urgent need to better understand how aging modifies alloimmune responses. Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses...
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| Veröffentlicht in: | PloS one 2009, Vol.4 (1), p.e4097-e4097 |
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| description | As increasing numbers of older people are listed for solid organ transplantation, there is an urgent need to better understand how aging modifies alloimmune responses. Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses to organ transplantation.
Using murine experimental models, we found that aging impaired the host environment to expand and activate antigen specific CD8(+) T cells. Additionally, aging impaired the ability of polyclonal T cells to induce acute allograft rejection. However, the alloimmune priming capability of donor dendritic cells was preserved with aging.
Aging impairs recipient responses, both T cell intrinsic and extrinsic, in response to organ transplantation. |
| doi_str_mv | 10.1371/journal.pone.0004097 |
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Using murine experimental models, we found that aging impaired the host environment to expand and activate antigen specific CD8(+) T cells. Additionally, aging impaired the ability of polyclonal T cells to induce acute allograft rejection. However, the alloimmune priming capability of donor dendritic cells was preserved with aging.
Aging impairs recipient responses, both T cell intrinsic and extrinsic, in response to organ transplantation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0004097</identifier><identifier>PMID: 19119314</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aging ; Aging (artificial) ; Aging - immunology ; Analysis ; Animal models ; Animals ; Antigen-Presenting Cells - immunology ; Antigens ; CD8 antigen ; Dendritic cells ; Dendritic Cells - immunology ; Experiments ; Graft rejection ; Graft Rejection - immunology ; Homeostasis ; Humans ; Immunity ; Immunology ; Immunology/Immune Response ; Immunology/Leukocyte Activation ; Internal medicine ; Ligands ; Lymphocytes ; Lymphocytes T ; Medicine ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Older people ; Organ transplantation ; Priming ; Rodents ; Skin ; Spleen ; Spleen - cytology ; T cells ; T-Lymphocytes - immunology ; Transplantation ; Transplantation Immunology - immunology ; Transplantation Tolerance - immunology ; Transplantation, Homologous - immunology ; Transplants & implants</subject><ispartof>PloS one, 2009, Vol.4 (1), p.e4097-e4097</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Shen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Shen et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-84beb4fc267c03384bec28622f7a8efdb4345ca356553b025253179c944c21cd3</citedby><cites>FETCH-LOGICAL-c693t-84beb4fc267c03384bec28622f7a8efdb4345ca356553b025253179c944c21cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606020/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606020/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,4010,23845,27900,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19119314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Hua</creatorcontrib><creatorcontrib>Tesar, Bethany M</creatorcontrib><creatorcontrib>Du, Wei</creatorcontrib><creatorcontrib>Goldstein, Daniel R</creatorcontrib><title>Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>As increasing numbers of older people are listed for solid organ transplantation, there is an urgent need to better understand how aging modifies alloimmune responses. Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses to organ transplantation.
Using murine experimental models, we found that aging impaired the host environment to expand and activate antigen specific CD8(+) T cells. Additionally, aging impaired the ability of polyclonal T cells to induce acute allograft rejection. However, the alloimmune priming capability of donor dendritic cells was preserved with aging.
Aging impairs recipient responses, both T cell intrinsic and extrinsic, in response to organ transplantation.</description><subject>Age</subject><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Aging - immunology</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Antigens</subject><subject>CD8 antigen</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Experiments</subject><subject>Graft rejection</subject><subject>Graft Rejection - immunology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Immunology/Immune Response</subject><subject>Immunology/Leukocyte Activation</subject><subject>Internal medicine</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Older people</subject><subject>Organ transplantation</subject><subject>Priming</subject><subject>Rodents</subject><subject>Skin</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>T cells</subject><subject>T-Lymphocytes - immunology</subject><subject>Transplantation</subject><subject>Transplantation Immunology - immunology</subject><subject>Transplantation Tolerance - immunology</subject><subject>Transplantation, Homologous - immunology</subject><subject>Transplants & implants</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoMo7jr6D0QLwoIXM-arSXojDIsfAwsLunonIU3TToZO0k1S0X9v6nR1RgQlF83H857mvDkHgKcIrhDh6NXOj8GpfjV4Z1YQQgorfg-co4rgJcOQ3D-an4FHMe4gLIlg7CE4QxXKZ4iegy_rzrqusPtB2RCLYLQdrHGpuCm06fvCuhSsi1YXyjWF-Xa3apVOPgusy5qY7xBNkXyRgnJx6JVLKlnvHoMHreqjeTJ_F-DT2zc3l--XV9fvNpfrq6VmFUlLQWtT01ZjxjUkZFpqLBjGLVfCtE1NCS21IiUrS1JDXOKSIF7pilKNkW7IAjw_xB16H-XsTJQIi4oKXOZcF2BzIBqvdnIIdq_Cd-mVlT83fOikCsnq3kiiSshrRkqkNcXYCKhoNow1gqsckORYr-e_jfXeNDrbFVR_EvT0xNmt7PxXiRlkMD_HAlzMAYK_HU1Mcm_jZLdyxo9RMsaFgFX1TxBDzLngPIMv_gD_bsLqQHUq52ld6_P1dB6N2Vud66i1eX9NOaGY4YpmwcsTQWZSroFOjTHKzccP_89efz5lL47YrVF92kbfj1PNxFOQHkAdfIzBtL9cRlBObXCXp5zaQM5tkGXPjl_ot2iue_IDYUgC2w</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Shen, Hua</creator><creator>Tesar, Bethany M</creator><creator>Du, Wei</creator><creator>Goldstein, Daniel R</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>2009</creationdate><title>Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation</title><author>Shen, Hua ; Tesar, Bethany M ; Du, Wei ; Goldstein, Daniel R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-84beb4fc267c03384bec28622f7a8efdb4345ca356553b025253179c944c21cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age</topic><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Aging - immunology</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Antigens</topic><topic>CD8 antigen</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Experiments</topic><topic>Graft rejection</topic><topic>Graft Rejection - immunology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunology</topic><topic>Immunology/Immune Response</topic><topic>Immunology/Leukocyte Activation</topic><topic>Internal medicine</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medicine</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Older people</topic><topic>Organ transplantation</topic><topic>Priming</topic><topic>Rodents</topic><topic>Skin</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>T cells</topic><topic>T-Lymphocytes - immunology</topic><topic>Transplantation</topic><topic>Transplantation Immunology - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Hua</au><au>Tesar, Bethany M</au><au>Du, Wei</au><au>Goldstein, Daniel R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009</date><risdate>2009</risdate><volume>4</volume><issue>1</issue><spage>e4097</spage><epage>e4097</epage><pages>e4097-e4097</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>As increasing numbers of older people are listed for solid organ transplantation, there is an urgent need to better understand how aging modifies alloimmune responses. Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses to organ transplantation.
Using murine experimental models, we found that aging impaired the host environment to expand and activate antigen specific CD8(+) T cells. Additionally, aging impaired the ability of polyclonal T cells to induce acute allograft rejection. However, the alloimmune priming capability of donor dendritic cells was preserved with aging.
Aging impairs recipient responses, both T cell intrinsic and extrinsic, in response to organ transplantation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19119314</pmid><doi>10.1371/journal.pone.0004097</doi><tpages>e4097</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aging Aging (artificial) Aging - immunology Analysis Animal models Animals Antigen-Presenting Cells - immunology Antigens CD8 antigen Dendritic cells Dendritic Cells - immunology Experiments Graft rejection Graft Rejection - immunology Homeostasis Humans Immunity Immunology Immunology/Immune Response Immunology/Leukocyte Activation Internal medicine Ligands Lymphocytes Lymphocytes T Medicine Mice Mice, Inbred C57BL Mice, Inbred CBA Older people Organ transplantation Priming Rodents Skin Spleen Spleen - cytology T cells T-Lymphocytes - immunology Transplantation Transplantation Immunology - immunology Transplantation Tolerance - immunology Transplantation, Homologous - immunology Transplants & implants |
| title | Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation |
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