A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans

The C. elegans eat-6 gene encodes a Na(+), K(+)-ATPase alpha subunit and is a homolog of the familial hemiplegic migraine candidate gene FHM2. Migraine is the most common neurological disorder linked to serotonergic dysfunction. We sought to study the pathophysiological mechanisms of migraine and th...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e10368-e10368
Hauptverfasser:	Govorunova, Elena G, Moussaif, Mustapha, Kullyev, Andrey, Nguyen, Ken C Q, McDonald, Thomas V, Hall, David H, Sze, Ji Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholinesterase Aldicarb Analysis Animals ATPases Caenorhabditis elegans Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - physiology Carbamates Drug delivery Drugs Electron microscopy Enzyme inhibitors Excitatory Postsynaptic Potentials - drug effects Genetics and Genomics/Disease Models Headache Homology Humans Hypersensitivity Migraine Migraine with Aura Models, Animal Modulation Motor neurons Mutation Na+/K+-exchanging ATPase Nematodes Nervous system diseases Neurological Disorders/Headache Neurological Disorders/Neurogenetics Neuromodulation Neurons Neurophysiology Neuroscience/Neural Homeostasis Neuroscience/Neuronal Signaling Mechanisms Neurotransmission Paralysis Phenols (Class of compounds) Phospholipase Phospholipase C Receptors Receptors, Serotonin RNA-mediated interference Serotonin Serotonin - pharmacology Signaling Sodium-Potassium-Exchanging ATPase - physiology Synaptic Transmission - drug effects Synaptic vesicles Worms
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