Stabilizing Role of Platelet P2Y12 Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

Background In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y12 receptors. However, such models do not predict involvement of P2Y12 in the clinically relevant situation of thro...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e10130
Hauptverfasser:	Nergiz-Unal, Reyhan, Cosemans, Judith M. E. M., Feijge, Marion A. H., van der Meijden, Paola E. J., Storey, Robert F., van Giezen, J. J. J., oude Egbrink, Mirjam G. A., Heemskerk, Johan W. M., Kuijpers, Marijke J. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Adenosine Adenosine diphosphate Animal models Apolipoprotein E Arteries Arteriosclerosis Atherosclerosis Biochemistry Blockage Blood Blood clots Blood platelets Blood vessels Cardiology Cardiovascular Disorders/Vascular Biology Carotid arteries Carotid artery Cell Biology/Cell Signaling Coagulation Collagen Embolization Fibrin Fluorescence Fluorescence microscopy Hematology In vivo methods and tests Pharmacology Physiology/Cardiovascular Physiology and Circulation Plaques Platelets Receptors Rodents Rupture Rupturing Shear flow Shear rate Signaling Stabilization Studies Thromboembolism Thrombosis Ultrasound Veins & arteries
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